28/12/2021 - 12:00 - 11:00
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2021-12-28 11:00:00
2021-12-28 12:00:00
Special Seminar-Prof. Olga Gursky
הרצאתה של פרופ אולגה גורסקי תתקיים ביום שלישי 28/12 בשעה 11:00 בחדר הסמינרים המחלקתי 211/112.
The Department of Chemistry Special Seminar will take place on Tuesday 28/12/21, 11:00pm in the Department seminar room 211/112.
On the “Serum amyloid A in lipid transport, inflammation, and amyloid disease: an ancient protein that wears hydrophobicity on its sleeve”
Prof. Olga Gursky
Boston University School of Medicine
Abstract
Serum amyloid A (SAA) is an ancient enigmatic biomarker of inflammation and a protein precursor of AA amyloidosis, a life-threatening complication of chronic inflammation. The levels of this small soluble intrinsically disordered protein increase rapidly and dramatically up to 1,000- fold in blood following inflammation, infection or injury. The advantage for survival of this steep but transient increase is unclear, and the beneficial role of SAA in immune response is obscure. However, evolutionarily conserved aspects of the SAA structure, the rapid and major commitment of liver to its generation in acute phase response, and its lipophilic character indicate the vital role of SAA-lipid interactions. Our studies use a wide array of structural and biochemical methods to reveal a new role for SAA in clearing cellular membrane debris from the injured sites. We propose that SAA acts as a lipid scavenger and an intrinsically disordered protein hub in the inflammation control. We also explore molecular mechanism of SAA misfolding in AA amyloidosis, a major form of systemic amyloid disease in animals and humans. Together, these studies help establish raison d’etre for this enigmatic Cambrian protein, provide a molecular basis for its action in immune response and lipid homeostasis, and help find much-needed therapies for a life-threatening human disease.
Abstract (PDF)
חדר הסמינרים 211/112
Department of Chemistry
chemistry.office@biu.ac.il
Asia/Jerusalem
public
מיקום
חדר הסמינרים 211/112
הרצאתה של פרופ אולגה גורסקי תתקיים ביום שלישי 28/12 בשעה 11:00 בחדר הסמינרים המחלקתי 211/112.
The Department of Chemistry Special Seminar will take place on Tuesday 28/12/21, 11:00pm in the Department seminar room 211/112.
On the “Serum amyloid A in lipid transport, inflammation, and amyloid disease: an ancient protein that wears hydrophobicity on its sleeve”
Prof. Olga Gursky
Boston University School of Medicine
Abstract
Serum amyloid A (SAA) is an ancient enigmatic biomarker of inflammation and a protein precursor of AA amyloidosis, a life-threatening complication of chronic inflammation. The levels of this small soluble intrinsically disordered protein increase rapidly and dramatically up to 1,000- fold in blood following inflammation, infection or injury. The advantage for survival of this steep but transient increase is unclear, and the beneficial role of SAA in immune response is obscure. However, evolutionarily conserved aspects of the SAA structure, the rapid and major commitment of liver to its generation in acute phase response, and its lipophilic character indicate the vital role of SAA-lipid interactions. Our studies use a wide array of structural and biochemical methods to reveal a new role for SAA in clearing cellular membrane debris from the injured sites. We propose that SAA acts as a lipid scavenger and an intrinsically disordered protein hub in the inflammation control. We also explore molecular mechanism of SAA misfolding in AA amyloidosis, a major form of systemic amyloid disease in animals and humans. Together, these studies help establish raison d’etre for this enigmatic Cambrian protein, provide a molecular basis for its action in immune response and lipid homeostasis, and help find much-needed therapies for a life-threatening human disease.
Abstract (PDF)
