06/04/2022 - 12:00 - 11:00
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2022-04-06 11:00:00
2022-04-06 12:00:00
קולוקוויום מחלקתי 6.04.2022
הקולוקויום יתקיים ביום שרביעי 6.04.2022 בשעה 11:00 בחדר הסמינרים המחלקתי (211/112).
The Department of Chemistry Weekly Seminar will take place on Wednesday 6.04.2022, 11:00 am in the Department seminar room 211/112.
DNA Nanoelectronics, Gold Nanoparticles, and Targeted Delivery of Nanostructures to Cancer Cells
Prof. Alexander Kotlyar
The main focus of my presentation will be on sensitive electrical detection of minor quantities of nucleic acids, DNA and RNA. This multidisciplinary work is carried out in my laboratory in collaboration with Danny Porath from Hebrew University of Jerusalem, and Henrik Dietz from Technical University of Munich. I will present our experimental strategy in which binding of target DNA or RNA molecules to a molecular electronic chip composed of DNA origami and gold nanoparticles alters conductive properties of the circuit. I will mainly touch upon preparation and characterization of the chip. In relation to this, I will discuss synthesis of DNA-based nanowires including: conjugates of G-rich DNA molecules with silver ions, conjugates of double stranded DNA molecules with gold nanoparticles and G4-DNA based nanostructures. I will also address an issue of synthesis of novel small (2 nm in diameter) gold nanoparticles which can be readily conjugated with DNA and further enlarged on the DNA template, creating a highly conductive wire.
In addition, I’ll address an issue of targeted delivery of various nanostructures including: gold nanoparticles, gold nanorods and liposomes loaded with different bioactive compounds to cancer cells. Our strategy is to conjugate the above nanostructures with antibody mimicking proteins, DARPins (designed ankyrin repeat proteins), creating constructs that specifically interact with receptors overexpressed on the surface of cancer cells.
I will also briefly address an issue of gold nanoparticles assembling on mica. We have recently found that under certain conditions the particles are self-assemble into highly ordered coating layer on a mica surface.
חדר הסמינרים 211/112, Department seminar room
Department of Chemistry
chemistry.office@biu.ac.il
Asia/Jerusalem
public
מיקום
חדר הסמינרים 211/112, Department seminar room
הקולוקויום יתקיים ביום שרביעי 6.04.2022 בשעה 11:00 בחדר הסמינרים המחלקתי (211/112).
The Department of Chemistry Weekly Seminar will take place on Wednesday 6.04.2022, 11:00 am in the Department seminar room 211/112.
DNA Nanoelectronics, Gold Nanoparticles, and Targeted Delivery of Nanostructures to Cancer Cells
Prof. Alexander Kotlyar
The main focus of my presentation will be on sensitive electrical detection of minor quantities of nucleic acids, DNA and RNA. This multidisciplinary work is carried out in my laboratory in collaboration with Danny Porath from Hebrew University of Jerusalem, and Henrik Dietz from Technical University of Munich. I will present our experimental strategy in which binding of target DNA or RNA molecules to a molecular electronic chip composed of DNA origami and gold nanoparticles alters conductive properties of the circuit. I will mainly touch upon preparation and characterization of the chip. In relation to this, I will discuss synthesis of DNA-based nanowires including: conjugates of G-rich DNA molecules with silver ions, conjugates of double stranded DNA molecules with gold nanoparticles and G4-DNA based nanostructures. I will also address an issue of synthesis of novel small (2 nm in diameter) gold nanoparticles which can be readily conjugated with DNA and further enlarged on the DNA template, creating a highly conductive wire.
In addition, I’ll address an issue of targeted delivery of various nanostructures including: gold nanoparticles, gold nanorods and liposomes loaded with different bioactive compounds to cancer cells. Our strategy is to conjugate the above nanostructures with antibody mimicking proteins, DARPins (designed ankyrin repeat proteins), creating constructs that specifically interact with receptors overexpressed on the surface of cancer cells.
I will also briefly address an issue of gold nanoparticles assembling on mica. We have recently found that under certain conditions the particles are self-assemble into highly ordered coating layer on a mica surface.
