English

ד"ר עבד סעדי

דוא"ל
Abed.Saady@biu.ac.il
אתר אישי
https://saadylab.com/
תחומי מחקר
כימיה אורגנית
קורות חיים

Dr. Abed Saady received all his degrees in Medicinal Chemistry from Bar-Ilan University. B.Sc. in 2015 (with distinction), M.Sc. in 2016 (with honors), and Ph.D. in 2020 under the supervision of Professor B. Fischer. At the end of his Ph.D. (August 2020), he moved to the Technion to work with Professor S. Berlin and Professor M. Eisen on the development of a new generation of MRI contrast agent. In 2021, he moved to the University of Southampton-UK (2023, University of Birmingham-UK) as a VATAT postdoctoral fellow to work with Professor S. Goldup on the synthesis of chiral mechanically interlocked molecules MIMs, and their biological applications. In June 2024, he joined the Department of Chemistry at Bar-Ilan University as an assistant professor of organic and supramolecular chemistry. 

Current and previous positions 

Assistant Professor Department of Chemistry Bar-Ilan University.  2024 - present
Senior Postdoctoral Fellow with Prof. Stephen M Goldup. School of Chemistry - University of Birmingham- UK.  2023 - 2024
Postdoctoral researcher with Prof. Stephen M Goldup. School of Chemistry, University of Southampton- UK.  2021 - 2023 
Postdoctoral researcher with Prof. Moris Eisen and Prof. Shai Berlin. Schulich Faculty of Chemistry, Technion – Israel. 2020 - 2021

 

Education

Ph.D. in Medicinal and Organic Chemistry. Department of Chemistry, Bar-Ilan University.  2016- 2020
M.Sc. in Medicinal and Organic Chemistry, summa cum laude. Department of Chemistry, Bar-Ilan University. 2015- 2016
B.Sc. in Medicinal Chemistry, summa cum laude. Department of Chemistry, Bar-Ilan University. 2012- 2015  
 

 

מחקר

Mechanically interlocked molecules for Biological Applications 

Research in the Saady Group is driven by the development of rotaxanes for biological and medicinal applications such as prodrugs, drug delivery, MRI contrast agents and cell imaging. In particular, we target to synthesize cyclodextrin (CD)-based rotaxanes as a promising candidate to exploring the use of functional rotaxanes in biological applications.

Mechanically interlocked molecules for Biological Applications
פרסומים

  1. Abed Saady, Georgia Malcolm, Matthew Fitzpatrick, Noel Pairault ,Graham Tizzard ,Soran Mohammed, Ali Tavassoli and Stephen M. Goldup. A platform approach to functional, caged interlocked molecules. Accepted, Angew. Chem., Int. Ed. Engl. 2024.(Link) 

  1. Andrea Savoini,# Peter Gallagher,# Abed Saady, Graham Tizzard, John R. J. Maynard, Patrick Butler and Stephen M. Goldup. Facial Selectivity in Mechanical Bond Formation: Axially Chiral Enan-tiomers and Geometric Isomers from a Simple Prochiral Macrocycle. J. Am. Chem. Soc. 2024, 146, 13, 9134–9141. #Authors have equally contributed to the manuscript. (Link) 

  1. Andrea Savoini,# Peter Gallagher,# Abed Saady,# and Stephen M. Goldup. The Final Stereogenic Unit of [2]Rotaxanes: Type 2 Geometric Isomers. J. Am. Chem. Soc. 2024, 146, 12, 8472–8479. #Authors have equally contributed to the manuscript. (Link) 

  1. Abed Saady and Stephen Goldup. Triazole Formation and the Click Concept in the Synthesis of Interlocked Molecules. Chem (5), 2110-2127, (2023). (Link) 

  1. Abed Saady,# Ebaston Thankarajan,# Shimrit Oz,# Kseniya Kulbitski, Mykhail Kompanets, Moris S. Eisen, Shai Berlin. SNAP-targeted MRI-Fluorescent agents for multimodal imaging. ChemBioChem, 24, 1172- 1186, (2023). #Authors have equally contributed to the manuscript. (Link) 

  1. Shu Zhang#, Arnau Rubio#, Abed Saady, Graham Tizzard and Stephen Goldup. A Chiral Macrocycle for the Synthesis of Both Mechanically Planar Chiral Rotaxanes and Catenanes in Excellent Enantiopurity. Chem (5), 1195-1207, (2023). #Authors have equally contributed to the manuscript. (Link) 

  1. Molhm Nassir, Abed Saady, Natalie Pariene Cohen and Bilha Fischer. The Synthesis of Nucleoside 2′, 3′‐Cyclic Monophosphate Analogs with Regio‐and Stereospecificity. Current Protocols in Nucleic Acid Chemistry ,1 (11), e287. (2021). (Link) 

  1. Kusha Sharma, Abed Saady, Avi Jacob, Ze’ev Porac and  Aharon Gedanken. Entrapment and release kinetics study of dyes from BSA microspheres forming a matrix and a reservoir system. J. Mater. Chem. B, 8, 10154-10161. (2020). (Link) 

  1. Gil Otis, Molhm Nassir, Michael Zutta, Abed Saady, Sharon Ruthstein and Yitzhak Mastai. Enantioselective crystallization of chiral inorganic crystals of -Zn(OH)2 with amino acids. Angew. Chem. Int. Ed. 2020, 59, 1 – 7. Hot Paper. (Link) 

  1. Abed Saady,# Elena Benisvy-Aharonovich#, Anat Zandany#, Yael Kinel-Tahan, Yaron Yehoshua and Aharon Gedanken. An efficient method for the production of 1,4-pentanediol from the biomass of the algae Chlorella ohadi with levulinic acid as intermediate. (2020). Bioresource Technology Reports 11 (2020) 100514. #Authors have equally contributed to the manuscript. (Link) 

  1. Abed Saady, Melissa Meng, Eli Varon, Verena Böttner, Noa Kinor, Yaron Shav-Tal, Christian Ducho, and Bilha Fischer. Specific, sensitive, and quantitative detection of HER-2 mRNA breast cancer marker by fluorescent light-up hybridization probes. Bioconjugate Chem. 2020, 31, 4, 1188–1198. (Link) 

  1. Abed Saady, Noam Y. Steinman, Melissa Wojtyniak, Christian Ducho and Bilha Fischer. Synthesis of 2’-deoxyuridine modified with 3,5-difluoro-4-methoxybenzylidene imidazolinone (DFMBI) derivative for incorporation into oligonucleotide probes for detection of HER2 breast cancer marker. Current Protocols in Nucleic Acid Chemistry, 80, e104. doi: 10.1002/cpnc.104, (2020). (Link) 

  1. Abed Saady, Eli Varon, Avi Jacob, Yaron Shav-Tal and Bilha Fischer. Applying styryl quinolinium fluorescent probes for imaging of ribosomal RNA in living cells. Dyes and Pigments, (2020): 107986. (Link) 

  1. Abed Saady, Pagidi Sudhakar, Molhm Nassir and Aharon Gedanken. Ultrasonic assisted synthesis of styrylpyridinium dyes: Optical properties and DFT calculations. (2020). Ultrasonics Sonochemistry. (2020): 105182. (Link) 

  1. Abed Saady and Bilha Fischer. Synthesis and Photophysical Properties of Conjugates of Green Fluorescent Protein (GFP) Chromophore and 2’-deoxy-Uridine as Potential Probes. J. Pharm. Pharmacol. 7 (2019) 510-519. (Link) 

  1. Abed Saady, Verena Böttner, Melissa Meng, Eli Varon, Yaron Shav-Tal, Christian Ducho, and Bilha Fischer. An Oligonucleotide Probe Incorporating the Chromophore of Green Fluorescent Protein is Useful for the Detection of HER-2 Breast Cancer. Eur. J. Med. Chem 173 (2019) 99-106. (Link) 

  1. Amruta Mutalikdesai, Molham Nassir, Abed Saady, Alfred Hassner and Aharon Gedanken. Sonochemically modified ovalbumin enhances enantioenrichment of some amino acids. Ultrasonics Sonochemistry 58 (2019): 104603. (Link) 

  1. Vijay Bhooshan Kumar, Yael Steinberg, Ze'ev Porat, Molhm Nassir, Abed Saady, Alfred Hassner and Aharon Gedanken. ChemistrySelect, 2, (2017).  (27), 8234-8238.‏ (Link) 

תאריך עדכון אחרון : 12/08/2024