Prof. Yitzhak Mastai

Nano Bldg. 206, Room C268. Laboratory: Nano Bld. 206, Room C261/2/3/4, Laboratory Phone: 077-3063255

    Research Summary

    My primary field of research is chirality at the nanoscale, with a focus on preparation and application of nano-chiral surfaces for enantioselective processes. My research interests can be divided into several areas:

    Chiral surfaces based on self-assembled monolayers

    This research concerns fundamental studies of chiral surfaces based on ultrathin molecular architectures, such as self-assembled monolayers (SAMs), on solid supports. We were pioneers in the study of chiral SAMs for the preparation of chiral nanosurfaces for chiral resolution by crystallization. In a series of papers, our research group has shown that chiral SAM surfaces can be employed as resolving auxiliaries in the crystallization of amino acids from solutions. Recently we presented an innovative new type of chiral surface based on a chiral SAM coated with ceramic nanolayers that preserves the enantioselectivity nature of the chiral SAM and enables its protection. These surfaces can lead to a new class of chiral nano-surfaces with the improved characteristics that are necessary for any chiral application.



    Chiral polymeric nanoparticles

    This research concerns the development of polymeric nanoparticles fabricated using emulsion (mini or micro) polymerization. For example, we developed chiral polymeric nano- and microspheres that can act as chiral auxiliaries and be utilized for enantioselective crystallization. We are also developing chiral polymeric nanoparticles of controlled size and shape for other chiral applications such as a chiral stationary phase for chromatographic separations and as catalytic systems for stereoselective reactions.


    Chiral mesoporous silica

    Our group is also involved in the development of chiral mesoporous silica by chiral imprinting or by cooperative self-assembly of chiral amphiphiles and silica precursors. Our research focuses on the fabrication of chiral mesoporous materials and exploring the mechanisms involved in their formation and their chiral recognition.


    New chiral analytical techniques

    The group is also working on the development of new analytical methods to probe chirality at the nano-scale. We pioneered the development of near-field scanning optical microscopy (NSOM) and isothermal titration calorimetry (ITC) for the determination of chirality at the nanoscale.


    Research Grants:


    Funding Organization

    Research Topics

    Total ($)


    GIF young scientists P.I

    Polymers mimicking antifreeze proteins.



    Israel Academy for higher education

    Yigal Alon fellowship



    Pollack Foundation P.I.




    ISF Role - P.I.

    Laboratory for new faculty member



    ISF Role - P.I.

    Hydration of polyelectrolytes and biological macromolecules.



    German-Israeli cooperation in water technology research.

    Miniemulsion polymerization of cyclodextrins nanoporous beads for water purification application



    German-Israeli cooperation in water technology research.

    Small-Angle X-Ray Scattering (SAXS) study of water in modified mesoporous silica: applications for desalination systems.



    Converging technologies equipment grant (ISF) P.I

    Rutherford Backscattering spectrometry



    Ministry of Defence Israel (M.O.D)




    Horvitz foundation P.I

    Antifreeze proteins: from nature to industry - from basic research to business opportunity



    Katz Family Research Grant Incentive.

    Nanostructured Surfaces for Prevention of Biofilm Formation.



    ISF Role P.I

    Imprinting Chirality in Mesoporous Structures and its Application in Chiral Resolution.



    Equipment grant (ISF) together with Prof. Sukenik and Dr. Tischler

    Atomic Force Microscope with Raman Spectroscopy.



    Israel Science Foundation

    Chiral polymeric nanoparticles for enantioselective applications.



    Bar Ilan University – Rabin Medical Center Collaborative Grant Proposals in Biomedical Research,

    Dr. David Lifshitz

    Biomimetic polymers for passivation of hydroxyapatite plaques.




    Ministry of Defence Israel (M.O.D)




    Ministry of Health, ERA - NET

    Engineered nanotools for advanced cell therapies.



    Israel Ministry of Economy (Magnet מגנ"ט).

    SHPS-Super Hydrophobic Plastic Surfaces.



    German-Israeli Foundation (GIF)

    Enantioselective mesoporous carbon based on chiral ionic liquids.



    Israel Science Foundation

    Chiral metal oxides surfaces: synthesis, characterization and applications.


    Neutron beam and synchrotron radiation time grants


    Funding Organization

    Research Topics

    August 2005

    Intense Pulsed Neutron Source (IPNS), Argonne National  Laboratory USA.

    Inelastic neutron scattering studies of water in porous silica.

    December 2006

    I.S.I.S Rutherford Appleton Laboratory, United Kingdom.

    Neutron scattering of water in porous silica.

    May  2007

    I.L.L, Institute Laue-Langevin Grenoble France.

    Water in porous materials.

    January  2008

    Intense Pulsed Neutron Source (IPNS), Argonne National Laboratory.

    Structure of water in mesoporous organosilica by calorimetry and inelastic neutron scattering.

    April 2013


    The structure of mercury-supported Langmuir films of ionic liquids.

    May 2016


    Neutron scattering of amino acids and dipeptide.







    Refereed Papers

    1. Homyonfer, M.; Mastai, Y.; Hershfinkel, M.; Volterra, V.; Hutchison, J. L.; Tenne, R., Scanning tunneling microscope induced crystallization of fullerene-like MoS2Journal of the American Chemical Society 1996, 118, 7804-7808.
    2. Mastai, Y.; Hodes, G., Size quantization in electrodeposited CdTe nanocrystalline films. Journal of Physical Chemistry B 1997, 101, 2685-2690.
    3. Avivi, S.; Mastai, Y.; Hodes, G.; Gedanken, A., Sonochemical hydrolysis of Ga3+ ions: Synthesis of scroll-like cylindrical nanoparticles of gallium oxide hydroxide. Journal of the American Chemical Society 1999, 121, 4196-4199.
    4. Gal, D.; Mastai, Y.; Hodes, G.; Kronik, L., Band gap determination of semiconductor powders via surface photovoltage spectroscopy. Journal of Applied Physics 1999, 86, 5573-5577.
    5. Mastai, Y.; Homyonfer, M.; Gedanken, A.; Hodes, G., Room temperature sonoelectrochemical synthesis of molybdenum sulfide fullerene-like nanoparticles. Advanced Materials 1999, 11, 1010-1013.
    6. Mastai, Y.; Polsky, R.; Koltypin, Y.; Gedanken, A.; Hodes, G., Pulsed sonoelectrochemical synthesis of cadmium selenide nanoparticles. Journal of the American Chemical Society 1999, 121, 10047-10052.
    7. Palchik, O.; Kataby, G.; Mastai, Y.; Gedanken, A., New method for nanofabrication of structures analogous to "Core-Shell" vesicles. Advanced Materials 1999, 11, 1289.
    8. Shafi, K.; Felner, I.; Mastai, Y.; Gedanken, A., Olympic ring formation from newly prepared barium hexaferrite nanoparticle suspension. Journal of Physical Chemistry B 1999, 103, 3358-3360.
    9. Zhong, Z. Y.; Mastai, Y.; Koltypin, Y.; Zhao, Y. M.; Gedanken, A., Sonochemical coating of nanosized nickel on alumina submicrospheres and the interaction between the nickel and nickel oxide with the substrate. Chemistry of Materials 1999, 11, 2350-2359.
    10. Avivi, S.; Mastai, Y.; Gedanken, A., A new fullerene-like inorganic compound fabricated by the sonolysis of an aqueous solution of TlCl3Journal of the American Chemical Society 2000, 122, 4331-4334.
    11. Avivi, S.; Mastai, Y.; Gedanken, A., Sonohydrolysis of In3+ ions: Formation of needlelike particles of indium hydroxide. Chemistry of Materials 2000, 12, 1229-1233.
    12. Engelhard, T.; Jones, E. D.; Viney, I.; Mastai, Y.; Hodes, G., Deposition of tellurium films by decomposition of electrochemically-generated H2Te: application to radiative cooling devices. Thin Solid Films 2000, 370, 101-105.
    13. Jeevanandam, P.; Koltypin, Y.; Gedanken, A.; Mastai, Y., Synthesis of alpha-cobalt (II) hydroxide using ultrasound radiation. Journal of Materials Chemistry 2000, 10, 511-514.
    14. Jeevanandam, P.; Koltypin, Y.; Mastai, Y.; Gedanken, A., Sonochemical synthesis of lead hydroxy bromide needles. Journal of Materials Chemistry 2000, 10, 2143-2146.
    15. Kumar, R. V.; Mastai, Y.; Gedanken, A., Sonochemical synthesis and characterization of nanocrystalline paramelaconite in polyaniline matrix. Chemistry of Materials 2000, 12, 3892-3895.
    16. Liu, S. W.; Tang, X. H.; Mastai, Y.; Felner, I.; Gedanken, A., Preparation and characterization of iron-encapsulating carbon nanotubes and nanoparticles. Journal of Materials Chemistry 2000, 10, 2502-2506.
    17. Liu, S. W.; Zhu, J. J.; Mastai, Y.; Felner, I.; Gedanken, A., Preparation and characteristics of carbon nanotubes filled with cobalt. Chemistry of Materials 2000, 12, 2205-2211.
    18. Mastai, Y.; Gal, D.; Hodes, G., Nanocrystal-size control of electrodeposited nanocrystalline semiconductor films by surface capping. Journal of the Electrochemical Society 2000, 147, 1435-1439.
    19. Zaban, A.; Aruna, S. T.; Tirosh, S.; Gregg, B. A.; Mastai, Y., The effect of the preparation condition of TiO2 colloids on their surface structures. Journal of Physical Chemistry B 2000, 104, 4130-4133.
    20. Zhong, Z. Y.; Mastai, Y.; Salkar, R. A.; Koltypin, Y.; Gedanken, A., Preparation and coating of molybdenum oxide on alumina submicrospheres by sonochemical method. Journal of Materials Research 2000, 15, 393-401.
    21. Antonietti, M.; Landfester, K.; Mastai, Y., The vision of "Nanochemistry", or is there a promise for specific chemical reactions in nano-restricted environments? Israel Journal of Chemistry 2001, 41, 1-5.
    22. Kumar, R. V.; Mastai, Y.; Diamant, Y.; Gedanken, A., Sonochemical synthesis of amorphous Cu and nanocrystalline Cu2O embedded in a polyaniline matrix. Journal of Materials Chemistry 2001, 11, 1209-1213.
    23. Mastai, Y.; Diamant, Y.; Aruna, S. T.; Zaban, A., TiO2 nanocrystalline pigmented polyethylene foils for radiative cooling applications: Synthesis and characterization. Langmuir 2001, 17, 7118-7123.
    24. Pang, G. S.; Sominska, E.; Colfen, H.; Mastai, Y.; Avivi, S.; Koltypin, Y.; Gedanken, A., Preparing a stable colloidal solution of hydrous YSZ by sonication. Langmuir 2001, 17, 3223-3226.
    25. Colfen, H.; Qi, L. M.; Mastai, Y.; Borger, L., Formation of unusual 10-petal BaSO4 structures in the presence of a polymeric additive. Crystal Growth & Design 2002, 2, 191-196.
    26. Mastai, Y.; Polarz, S.; Antonietti, M., Silica-carbon nanocomposites: A new concept for the design of solar absorbers. Advanced Functional Materials 2002, 12, 197-202.
    27. Mastai, Y.; Rudloff, J.; Colfen, H.; Antonietti, M., Control over the structure of ice and water by block copolymer additives. Chemphyschem 2002, 3, 119-123.
    28. Mastai, Y.; Sedlak, M.; Colfen, H.; Antonietti, M., The separation of racemic crystals into enantiomers by chiral block copolymers. Chemistry-a European Journal 2002, 8, 2430-2437.
    29. Nikitenko, S. I.; Koltypin, Y.; Mastai, Y.; Koltypin, M.; Gedanken, A., Sonochemical synthesis of tungsten sulfide nanorods. Journal of Materials Chemistry 2002, 12, 1450-1452.
    30. Rana, R. K.; Mastai, Y.; Gedanken, A., Acoustic cavitation leading to the morphosynthesis of mesoporous silica vesicles. Advanced Materials 2002, 14, 1414-1418.
    31. Sedlák, M.; Mastai, Y.; Cölfen, H.; Antonietti, M., The Disintegration of Racemic Crystals into Enantiomers by Chiral Block Copolymers Chemické Listy 2002, 96, 932-933.
    32. Dimova, R.; Lipowsky, R.; Mastai, Y.; Antonietti, M., Binding of polymers to calcite crystals in water: Characterization by isothermal titration calorimetry. Langmuir 2003, 19, 6097-6103.
    33. Dobson, K. D.; Hodes, G.; Mastai, Y., Thin semiconductor films for radiative cooling applications. Solar Energy Materials and Solar Cells 2003, 80, 283-296.
    34. Hornebecq, V.; Mastai, Y.; Antonietti, M.; Polarz, S., Redox behavior of nanostructured molybdenum oxide - Mesoporous silica hybrid materials. Chemistry of Materials 2003, 15, 3586-3593.
    35. Montenegro, R.; Antonietti, M.; Mastai, Y.; Landfester, K., Crystallization in miniemulsion droplets. Journal of Physical Chemistry B 2003, 107, 5088-5094.
    36. Pol, V. G.; Motiei, M.; Gedanken, A.; Calderon-Moreno, J.; Mastai, Y., Sonochemical deposition of air-stable iron nanoparticles on monodispersed carbon spherules. Chemistry of Materials 2003, 15, 1378-1384.
    37. Rana, R. K.; Zhang, L. Z.; Yu, J. C.; Mastai, Y.; Gedanken, A., Mesoporous structures from supramolecular assembly of in situ generated ZnS nanoparticles. Langmuir 2003, 19, (5904-5911.
    38. Patra, C.; Mastai, Y.; Gedanken, A., Microwave-assisted synthesis of submicrometer GaO(OH) and Ga2O3 rods. Journal of Nanoparticle Research 2004, 6, 509-518.
    39. Yu, S. H.; Colfen, H.; Mastai, Y., Formation and optical properties of gold nanoparticles synthesized in the presence of double-hydrophilic block copolymers. Journal of Nanoscience and Nanotechnology 2004, 4, 291-298.
    40. Katzen, D.; Levy, E.; Mastai, Y., Thin films of silica-carbon nanocomposites for selective solar absorbers. Applied Surface Science 2005, 248, 514-517.
    41. Menahem, T.; Mastai, Y., Chiral soluble polymers and microspheres for enantioselective crystallization. Journal of Polymer Science Part a-Polymer Chemistry 2006, 44, 3009-3017.
    42. Patra, C. R.; Patra, S.; Gabashvili, A.; Mastai, Y.; Koltypin, Y.; Gedanken, A.; Palchik, V.; Slifkin, M. A., A microwave route for the synthesis of nanoflakes and dendrites-type, beta-In2S3 and their characterization. Journal of Nanoscience and Nanotechnology 2006, 6, 845-851.
    43. Baruch, E.; Mastai, Y., Antifreeze properties of polyglycidol block copolymers. Macromolecular Rapid Communications 2007, 28, 2256-2261.
    44. Dressler, D. H.; Landau, A.; Zaban, A.; Mastai, Y., Sub-micrometer polarimetry of chiral surfaces using near-field scanning optical microscopy. Chemical Communications 2007, 945-947.
    45. Dressler, D. H.; Mastai, Y., Enantioselective crystallization of histidine on chiral self-assembled films of cysteine. Journal of Colloid and Interface Science 2007, 310, 653-660.
    46. Dressler, D. H.; Mastai, Y., Chiral crystallization of glutamic acid on self assembled films of cysteine. Chirality 2007, 19, 358-365.
    47. Dressler, D. H.; Mastai, Y., Controlling polymorphism by crystallization on self-assembled multilayers. Crystal Growth & Design 2007, 7, 847-850.
    48. Gabashvili, A.; Medina, D. D.; Gedanken, A.; Mastai, Y., Templating mesoporous silica with chiral block copolymers and its application for enantioselective separation. Journal of Physical Chemistry B 2007, 111, 11105-11110.
    49. Kun, H.; Byk, G.; Mastai, Y., Effects of antifreeze protein fragments on the properties of model membranes. Biopolymers 2007, 88, 637-637.
    50. Kun, H.; Mastai, Y., Activity of short segments of type I antifreeze protein. Biopolymers 2007, 88, 807-814.
    51. Medina, D. D.; Goldshtein, J.; Margel, S.; Mastai, Y., Enantioselective crystallization on chiral polymeric microspheres. Advanced Functional Materials 2007, 17, 944-950.
    52. Shinitzky, M.; Shvalb, A.; Elitzur, A. C.; Mastai, Y., Entrapped energy in chiral solutions: Quantification and information capacity. Journal of Physical Chemistry B 2007, 111, 11004-11008.
    53. Baruch, E.; Belostotskii, A. M.; Mastai, Y., Relationship between the antifreeze activities and the chemical structures of polyols. Journal of Molecular Structure 2008, 874, 170-177.
    54. Dressler, D. H.; Hod, I.; Mastai, Y., Stabilization of alpha-L-glutamic acid on chiral thin films - A theoretical and experimental study. Journal of Crystal Growth 2008, 310, 1718-1724.
    55. Fleger, Y.; Dressler, D. H.; Mastai, Y.; Rosenbluh, M., Surface enhanced Raman spectroscopy of aromatic compounds on silver nanoclusters. 2008 Quantum Electronics and Laser Science Conference (QELS) 2008.
    56. Kun, H.; Minnes, R.; Mastai, Y., Effects antifreeze peptides on the thermotropic properties of a model membrane. Journal of Bioenergetics and Biomembranes 2008, 40, 389-396.
    57. Mastai, Y.; Voelkel, A.; Coelfen, H., Separation of racemate from excess enantiomer of chiral nonracemic compounds via density gradient ultracentrifugation. Journal of the American Chemical Society 2008, 130, 2426-2427.
    58. Medina, D. D.; Mastai, Y., Synthesis of DL-alanine mesocrystals with a hollow morphology. Crystal Growth & Design 2008, 8, 3646-3651.
    59. Menahem, T.; Mastai, Y., Controlled crystallization of calcium carbonate superstructures in macroemulsions. Journal of Crystal Growth 2008, 310, 3552-3556.
    60. Menahem, T.; Mastai, Y., Enantioselective crystallization in miniemulsions based on chiral surfactants. New Journal of Chemistry 2008, 32, 925-928.
    61. Dryzun, C.; Mastai, Y.; Shvalb, A.; Avnir, D., Chiral silicate zeolites. Journal of Materials Chemistry 2009, 19, 2062-2069.
    62. Levy, E.; Kolesnikov, A. I.; Li, J.; Mastai, Y., Structure of water in mesoporous organosilica by calorimetry and inelastic neutron scattering. Surface Science 2009, 603, 71-77.
    63. Menahem, T.; Pravda, M.; Mastai, Y., Correlation between structures of chiral polymers and their efficiency for chiral resolution by crystallization. Chirality 2009, 21, (9), 862-870.
    64. Dressler, D. H.; Mastai, Y.; Rosenbluh, M.; Fleger, Y., Surface-enhanced Raman spectroscopy as a probe for orientation of pyridine compounds on colloidal surfaces. Journal of Molecular Structure 2009, 935, (1-3), 92-96.
    65. Fleger, Y.; Mastai, Y.; Rosenbluh, M.; Dressler, D. H., SERS as a probe for adsorbate orientation on silver nanoclusters. Journal of Raman Spectroscopy 2009, 40, (11), 1572-1577.
    66. Fleger, Y.; Mastai, Y.; Rosenbluh, M.; Dressler, D. H., Surface enhanced Raman spectroscopy of aromatic compounds on silver nanoclusters. Surface Science 2009, 603, (5), 788-793.. 
    67. Mastai, Y., Enantioselective crystallization on nanochiral surfaces. Chemical Society Reviews 2009, 38, (3), 772-780.
    68. Paik, P.; Gedanken, A.; Mastai, Y., Chiral separation abilities: Aspartic acid block copolymer-imprinted mesoporous silica. Microporous and Mesoporous Materials 2009, 129, (1-2), 82-89.
    69. Paik, P.; Gedanken, A.; Mastai, Y., Enantioselective separation using chiral mesoporous spherical silica prepared by templating of chiral block copolymers. ACS Applied Materials & Interfaces 2009, 1, (8), 1834-1842.
    70. Sivan, B.; Tikva, P.; Mastai, Y.; Fried, R.; Litshitz, D. A., The kinetics of Uric acid stones dissolution. Journal of Urology 2009, 181, (4), 519-520.
    71. Tamam, L.; Menahem, T.; Mastai, Y.; Sloutskin, E.; Yefet, S.; Deutsch, M., Langmuir Films of chiral molecules on mercury. Langmuir 2009, 25, (9), 5111-5119.
    72. Baruch-Teblum, E.; Mastai, Y.; Landfester, K., Miniemulsion polymerization of cyclodextrin nanospheres for water purification from organic pollutants. European Polymer Journal 2010, 46, (8), 1671-1678.
    73. Katsir, Y.; Shapira, Y.; Mastai, Y.; Dimova, R.; Ben-Jacob, E., Entropic effects and slow kinetics revealed in titrations of D2O-H2O solutions with different D/H ratios. Journal of Physical Chemistry B 2010, 114, (17), 5755-5763.
    74. Krattiger, P.; Nassif, N.; Voelkel, A.; Mastai, Y.; Wennemers, H.; Coelfen, H., Investigation of active crystal morphogenesis peptide sequences from peptide libraries by crystallization on peptide functionalized beads. Colloids and Surfaces a-Physicochemical and Engineering Aspects 2010, 354, (1-3), 218-225.
    75. Yitzhak Mastai, Milos Sedlák, Helmut Cölfen, Markus Antonietti: ChemInform Abstract: The Separation of Racemic Crystals into Enantiomers by Chiral Block Copolymers. Chemistry 2010; 8(11):2429-37.
    76. Kun, H.; Mastai, Y., Isothermal Calorimetry study of the interactions of Type I antifreeze proteins with a lipid model membrane. Protein and Peptide Letters 2010, 17, (6), 739-743.
    77. Levy, E.; Chan, L. K.; Yu, D.; Koza, M. M.; Mastai, Y.; Ford, R. C.; Li, J., Neutron scattering study of water confined in periodic mesoporous organosilicas. Journal of Solid State Chemistry 2010, 183, (7), 1691-1696.
    78. Paik, P.; Gedanken, A.; Mastai, Y., Chiral-mesoporous-polypyrrole nanoparticles: Its chiral recognition abilities and use in enantioselective separation. Journal of Materials Chemistry 2010, 20, (20), 4085-4093.
    79. Shvalb, A.; Mastai, Y.; Shinitzky, M., Chiral configuration of the hydration layers of D- and L-Alanine in water implied from dilution calorimetry. Chirality 2010, 22, (6), 587-592.
    80. Tamam, L.; Medina, D. D.; Menahem, T.; Mastai, Y.; Sloutskin, E.; Yefet, S.; Deutsch, M., The structure and phase diagram of chiral alkyl-serine monolayers on mercury. Soft Matter 2010, 6, (3), 526-541.
    81. Ejgenberg, M.; Mastai, Y., Conglomerate crystallization on self-assembled monolayers. Chemical Communications 2011, (47), 12161–12163
    82. Hod, I.; Mastai, Y.; Medina, D. D., Effect of solvents on the growth morphology of DL-alanine crystals. Crystengcomm 2011, 13, (2), 502-509.
    83. Medina, D. D.; Gedanken, A.; Mastai, Y., Chiral amplification in crystallization under ultrasound radiation. Chemistry-a European Journal 2011, 17, (40), 11139-11142.
    84. Shvalb, A.; Mastai, Y., Isothermal titration calorimetry as a new tool to investigate chiral interactions at crystal surfaces. Chemical Communications 2011, 47, (20), 5735-5737.
    85. Fried, R.; Mastai, Y., The effect of sulfated polysaccharides on the crystallization of calcite superstructures. Journal of Crystal Growth 2012,338, 147-151.
    86. Paik, P.; Mastai* Y.; Kityk I.; Piort Rakus P.; Gedanken A., Synthesis of Amino Acid Block-copolymer Imprinted Chiral Mesoporous Silica and its Acoustically-induced Optical Kerr Effects, Journal of Solid State Chemistry 2012, 192, 127-131.
    87. Ejgenberg, M.; Mastai, Y., Biomimetic Crystallization of L-Cystine Hierarchical Structures. Crystal Growth & Design 2012, 12 (10), 4995-5001.
    88. Kumar, V. B.; Annamanedi, M.; Prashad, M. D.; Arunasree, K. M.; Mastai, Y.; Gedanken, A.; Paik, P., Synthesis of mesoporous SiO2-ZnO nanocapsules: encapsulation of small biomolecules for drugs and "SiOZO-plex" for gene delivery. Journal of Nanoparticle Research 2013, 15 (9)
    89. Moshe, H.; Levi, G.; Mastai, Y., Polymorphism stabilization by crystal adsorption on a self-assembled monolayer. Crystengcomm 2013, 15 (44), 9203-9209.
    90. Moshe, H.; Vanbel, M.; Valev, V. K.; Verbiest, T.; Dressler, D.; Mastai, Y., Chiral Thin Films of Metal Oxide. Chemistry-a European Journal 2013, 19 (31), 10295-10301.
    91. Munoz-Espi, R.; Mastai, Y.; Gross, S.; Landfester, K., Colloidal systems for crystallization processes from liquid phase. Crystengcomm 2013, 15 (12), 2175-2191.
    92. Schatz, D.; Nagar, E.; Sendersky, E.; Parnasa, R.; Zilberman, S.; Carmeli, S.; Mastai, Y.; Shimoni, E.; Klein, E.; Yeger, O.; Reich, Z.; Schwarz, R., Self-suppression of biofilm formation in the cyanobacterium Synechococcus elongatus. Environmental Microbiology 2013, 15 (6), 1786-1794.
    93. Bhattacharyya, S.; Mastai, Y.; Panda, R. N.; Yeon, S.-H.; Hu, M. Z., Advanced Nanoporous Materials: Synthesis, Properties, and Applications. Journal of Nanomaterials 2014.
    94. Schatz, D.; Nagar, E.; Sendersky, E.; Parnasa, R.; Zilberman, S.; Carmeli, S.; Mastai, Y.; Shimoni, E.; Klein, E.; Yeger, O.; Reich, Z.; Schwarz, R., Self-suppression of biofilm formation in the cyanobacterium Synechococcus elongatus. Environmental Microbiology 2013, 15, (6), 1786-1794.
    95. Fuchs, I.; Aluma, Y.; Ilan, M.; Mastai, Y., Induced Crystallization of Amorphous Biosilica to Cristobalite by Silicatein. Journal of Physical Chemistry B 2014, 118 (8), 2104-2111.
    96. Hagay Moshe, Gila Levi, Daniel Sharon, Yitzhak Mastai, Atomic layer deposition of enantioselective thin film of alumina on chiral self-assembled-monolayer. Surface Science 629,88-93, 2014.
    97. Mathnw, Shinto P, Mondal, Prakash Chandra, Moshe, Hagay, Mastai, Yitzhak and Naaman, Ron, Non-magnetic organic/inorganic spin injector at room temperature Applied Physics Letters2014, 105,  242408.
    98. Sayan Bhattacharyya, Yitzhak Mastai, Rabi Narayan Panda, Sun-Hwa Yeon, Michael Z. Hu: Advanced Nanoporous Materials: Synthesis, Properties, and Applications. Journal of Nanomaterials 2014; 6,:1-2.
    99. Fuchs, I.; Aluma, Y.; Ilan, M.; Kityk, I.; Mastai, Y., Photoinduced electro-optics measurements of biosilica transformation to cristobalite. Journal of Solid State Chemistry 2015, 226, 231-236.
    100. Lieberman, R. N.; Green, U.; Segev, G.; Polat, M.; Mastai, Y.; Cohen, H., Coal fly ash as a potential fixation reagent for radioactive wastes. Fuel 2015, 153, 437-444;
    101. Kumar, V. B.; Mastai, Y.; Porat, Z. e.; Gedanken, A., Chiral imprinting in molten gallium. New Journal of Chemistry 2015, 39 (4), 2690-2696.
    102. Preiss, L. C.; Werber, L.; Fischer, V.; Hanif, S.; Landfester, K.; Mastai, Y.; Munoz-Espi, R., Amino-Acid-Based Chiral Nanoparticles for Enantioselective Crystallization. Advanced Materials 2015, 27 (17), 2728.
    103. Werber, L.; Preiss, L. C.; Landfester, K.; Munoz-Espi, R.; Mastai, Y., Isothermal Titration Calorimetry of Chiral Polymeric Nanoparticles. Chirality 2015, 27 (9), 613-618.
    104. Adler S.R.; Mastai Y. Chiral polymeric nanoparticles for aldol reaction, Reactive and Functional Polymers, 2015, 96, 1-4.
    105. Joseph Berry, Tonio Buonassisi, David A. Egger, Gary Hodes, Leeor Kronik, Yueh-Lin Loo, Igor Lubomirsky, Seth R. Marder, Yitzhak Mastai, Joel S. Miller, David B. Mitzi, Yaron Paz, Andrew M. Rappe, Ilan Riess, Boris Rybtchinski, Oscar Stafsudd, Vladan Stevanovic, Michael F. Toney, David Zitoun, Antoine Kahn, David Ginley and David Cahen, Hybrid Organic–Inorganic Perovskites (HOIPs): Opportunities and Challenges, Advanced Materials 2015, 27, 5102–5112.
    106. Fuchs, I. Fechler N., Antonietti M. and Mastai Y. Enantioselective nanoporous carbon based on chiral ionic liquids, Angewandte Chemie International Edition,  2015, 55, 408-412.
    107. Lieberman, R.N, Anker, Y., Font, O. Querol, X., Mastai, Y., Knop, Y. Cohen, H. Potential of Hazardous Waste Encapsulation in Concrete Compound Combination with Coal Ash and Quarry Fine Additives, Environmental Science & Technology 2015, 49, 14146-14155.
    108. Guliamov R, Mathew S, Vankayala K, Moshe H, Mastai Y, Naaman R. Chirality Induced Spin Selectivity For Memory Applications. Bulletin of the American Physical Society2015 60.
    109. T. Kabulov T., Nechipurenko S. V., Sailaukhanuly Y., Mastai Y., Yefremov S. A. and. Nauryzbayev M. K. Preparation and characterization of activated carbons prepared from wood waste and their application for gas separation. International Journal of Chemical Sciences, 2015 ,13, 747-758.
    110. Lidor-Shalev O., Aviv H. and Mastai Y. Assembly of Ordered Polystyrene Nanoparticles on Self-Assembled Monolayers, Journal of Research Updates in Polymer Science2016, 5 202-209.
    111. Elfassy E., Mastai Y, Diego Pontoni D. and Deutsch M. Liquid-Mercury-Supported Langmuir Films of Ionic Liquids: Isotherms, Structure, and Time Evolution, Langmuir2016, 32 (13) 3164–3173.
    112. Elfassy E., Mastai Y. , Salomon A, Cysteine sensing by plasmons of silver nanocubes. Journal of Solid State Chemistry2016, 241 110-114.
    113. Lieberman N.R., Querol X., Moreno N., Yitzhak Mastai Y., Haim Cohen H. Physical and Chemical Changes in Coal Fly Ash during Acidic or Neutral Wastes Treatment, and its' Effect on the Fixation Process. Fuel 2016, 184, 69-80.
    114. Levi G. Scolnik, Y. Mastai Y.; Imprinting chirality in silica nanotubes by N-stearoyl-serine template, ACS Applied Materials & Interfaces20168 23356–23361.
    115. Shalev O. L., Carmiel, Y, Gottesman R, Tirosha S. Mastai Y. Chiral templating of alumina nanofilms by the atomic layer deposition process. Chem. Commun., 2016, 52, 12072-12075 111.
    116. Nguyen, T. P. T., P. S. M. Cheung, L. Werber, J. Gagnon, R. Sivakumar, C. Lennox, A. Sossin, Y. Mastai, and L. A. Cuccia. Directing the Viedma ripening of ethylenediammonium sulfate using "Tailor-made" chiral additives. Chemical Communications201652, 12626-12629.
    117. Elfassy, E. Basel Y. and Mastai Y. Crystallization of amino acids at the chiral ionic liquid/water interface CrystEngComm2016, 18, 8769-8775.
    118. Preiss, L. C.; Wagner, M.; Mastai, Y.; Landfester, K.; Muñoz-Espí, R., Amino-Acid-Based Polymerizable Surfactants for the Synthesis of Chiral Nanoparticles. Macromolecular Rapid Communications 2016 , 37, (17), 1421-1426.
    119. Shalev O. L., Carmiel, Y, Pliatsikas N., Patsalas P. Mastai Y., Chiral Metal-Oxide Nanofilms by Cellulose Template Using Atomic Layer Deposition Process, ACS Nano, 2017 11 (5), 4753-4759.
    120. Kumar K. Vasudeva Rao Penugurti V.R, Levi G., Yitzhak Mastai Y., Manavathi B and Paik P , Bio-inspired synthesis of Hierarchical Self-Assembled Zinc phosphate nanostructure in presence of Cowpea Mosaic Virus: in vitro cell cycle, proliferation and prospective for tissue regeneration, Biomedical Materials2017.
    121. Kumar Yamala A., Nadella V., Mastai Y., Prakash H., Paik P. Poly-N-acryloyl-(L-phenylalanine methyl ester) hollow core nanocapsules facilitate sustained delivery of immunomodulatory drugs and exhibit adjuvant properties. Nanoscale , 2017.
    122. H Aviv, I Nemtsov, Y Mastai, YR Tischler Characterization of Crystal Chirality in Amino Acids Using Low-Frequency Raman Spectroscopy, Journal of Physical Chemistry A2017.
    123. Lieberman R.N.; Knop Y. Querol X. Moreno, N. Munoz-Quiros C. Mastai Y. Anker Y. Cohen, H. Environmental impact and potential use of coal fly ash and sub-economical quarry fine aggregates in concrete. Journal of Hazardous Materials, 2018, 344, 1043-1056.
    124. Dario Espino D., Haruvy-Manor Y., Bar Y., and Mastai Y. Radical Degradation Processes Initiated by Catalytic Nanoparticles of CoFe2O4 Towards Polymer Waste Application. Journal of Polymers and the Environment 27 March 2018.
    125. Dellis, S.; Pliatsikas, N.; Kalfagiannis, N.; Lidor-Shalev, O.; Papaderakis, A.; Vourlias, G.; Sotiropoulos, S.; Koutsogeorgis, D. C.; Mastai, Y.; Patsalas, P., Broadband luminescence in defect-engineered electrochemically produced porous Si/ZnO nanostructures. Scientific Reports 2018, 8, 6988.
    126. O Lidor-Shalev, Y Cramiel, N Pliatsikas, P Patsalas, Y Mastai Atomic layer deposition of metal-oxide thin films on cellulose fibers Journal of Coordination Chemistry2018 1-14.
    127. I Nemtsov, Y Mastai, M Ejgenberg, Formation of Hierarchical Structures of L-Glutamic acid with L-Arginine Additive, Cryst. Growth Des.2018, 18 (7), pp 4054–4059.
    128. Michal Ejgenberg, Yitzhak Mastai: Hierarchical superstructures of L-Glutathione. Crystal Growth & Design 2018; 18, 5063.
    129. I. Nemtsov Y. Mastai, Y.R Tischler H.Aviv, Chiral Purity of Crystals Using Low‐Frequency Raman Spectroscopy, ChemPhysChem, 2018, 19, 3116..
    130. S Sarma, I Fekas, K Filintoglou, J Arvanitidis, D Christofilos, E Hatzikraniotis, O Lidor, Y Mastai, A Unal and P Patsalas Layer by layer deposition of alternate carbon nanotubes and Ni films for efficient multilayer thin film temperature gauges. Journal of Physics D: Applied Physics, 2019, 52.
    131. D.D. Medina, Y. Mastai, Chiral Polymers and Polymeric Particles for Enantioselective Crystallization, Isr. J. Chem2018,58, 1. ]
    132. K. B. Ghosh, Wenyan Zhang, F. Tassinari, Y. Mastai, O. Lidor-Shalev, R. Naaman, P. Möllers, D. Nürenberg, H. Zacharias, J. Wei, E. Wierzbinski, and D. H. Waldeck, Controlling Chemical Selectivity in Electrocatalysis with Chiral CuO-Coated Electrodes The Journal of Physical Chemistry C 2019  DOI: 10.1021/acs.jpcc.8b12027
    133. Controlling Chemical Selectivity in Electrocatalysis with Chiral CuO-Coated Electrodes The Journal of Physical Chemistry C Article ASAP  DOI: 10.1021/acs.jpcc.8b12027


    Chapters in books

    1. Yitzhak Mastai: Crystallization on self assembled monolayers. Advances in Crystallization Processes, Edited by Y. Mastai, 04/2012: pages 39-58; InTech ISBN: 978-953-51-0581-7
    2. Dana D. Medina, Yitzhak Mastai: Biomimetic Polymers for Chiral Resolution and Antifreeze Applications. On Biomimetics, 08/2011; , ISBN: 978-953-307-271-5, DOI:10.5772/21082
    3. Gary Hodes, Yitzhak Mastai: Preparation of Nanocrystalline Semiconductor Materials. Encyclopedia of Electrochemistry, 12/2007 ISBN: 9783527610426.
    4. A. Gedanken, Y. Mastai: The Chemistry of Nanomaterials: Synthesis, Properties and Applications. The Chemistry of Nanomaterials: Synthesis, Properties and Applications, 01/2005: pages 113 - 169; ISBN: 9783527602476.


    Book editor

    1. Yitzhak Mastai: Advanced Topics in Crystallization. Edited by Yitzhak Mastai, 05/2015 InTech, ISBN: 978-953-51-2125-1.
    2. Yitzhak Mastai: Materials Science - Advanced Topics. Edited by Yiztahk Mastai, 06/2013 InTech, ISBN: 978-953-51-1140-5.
    3. Yitzhak Mastai: Advances in Crystallization Processes. Edited by Yiztahk Mastai, 08/2012 InTech, ISBN: 979-953-307-878-5.


    Proceedings (refereed)

    1. Mastai, Y., Enantioselective crystallization on nano chiral surfaces. Abstracts of Papers of the American Chemical Society 2009, 238.
    2. Fleger, Y., Dressler, D. H., Mastai, Y. and Rosenbluh, M. (2008); Surface enhanced Raman spectroscopy of aromatic compounds on silver nanoclusters. Lasers and Electro-Optics & Quantum Electronics and Laser Science Conference, 9, 2361-2362.
    3. Kun, H.; Byk, G.; Mastai, Y., Effects of antifreeze protein fragments on the properties of model membranes. In Peptides for Youth, 2009; Vol. 611, pp 85-86.
    4. Dehong Yu, Daniel Page, Jichen Li, Yitzhak Mastai, Michael Koza and Gordon Kearley,; Quasi-Elastic Neutron Scattering Study of Water Confined in Periodic Mesoporous Organosilicas , Proc. QENS/WINS 2012J. Phys. Soc. Jpn82 (2013) SA011.
    5. Albeck, A.; Chill, J. H.; Fischer, B.; Mastai, Y.; Nudelman, A.; Wilson-Gordon, A. D., Department of Chemistry, Bar-Ilan University (BIU). Israel Journal of Chemistry 2014, 54 (10), 1488-1499.
    6. S. Avivi, Y. Mastai, A. Gedanken: ChemInform Abstract: Sonohydrolysis of In3+ Ions: Formation of Needlelike Particles of Indium Hydroxide. ChemInform 08/2010; 31(34).
    7. S. Avivi, Y. Mastai, A. Gedanken: ChemInform Abstract: A New Fullerene-Like Inorganic Compound Fabricated by the Sonolysis of an Aqueous Solution of TlCl3. ChemInform 08/2010; 31(32).


    Highlighted articles on our research

    1. H. Dryzun, Y. Mastai, A. Shvalb and D. Avnir, Highlighted in Science, 323 (5919), 1266 (2009) our  paper " Chiral silicate zeolites"
    2. Elinor Richards "A close look at chirality", Chemical Technology, 08 February 2007, highlighting our research on polarized near-field scanning optical microscopy (NSOM) for chirality of nanoscopic surfaces.
    3. "Chirality detection on nanoscopic surfaces", 24 January 2007, Hot article, Chemical Communications.


    1. Y. Mastai, M. Homynofer, R. Tenne, G. Hodes “Synthesis of inorganic fullerene-like nanoparticles of metal chalcogenides” Israel patent No.130, 915 1999, PCT-International patent No. WO01/04382, 2002.
    2. Hagit Kun and Y. Mastai "Activity of Short Segments of Type I Antifreeze Protein." USA provisional patent 2009.
    3. Irena Nemtsov, Yaakov R. Tischler, Hagit Aviv, Yitzhak Mastai Mastai “Chiral Purity of Crystals Using Low-Frequency Raman Spectroscopy” USA provisional patent 2018.
    4. Shalom Avadyayev and Yitzhak Mastai, Cyclodextrin polymeric Nanoparticles and Membrane Designing for Water Purification from Organic Contamination. USA provisional patent 2018.

    Undergraduate courses:

    "Inorganic Chemistry" and "Physical chemistry laboratory".

    Graduate courses (M.Sc and PhD):

    "Chemistry of Colloids and Surfaces"

    "Introduction to nanomaterials"

    "Introduction to solid state chemistry"





    1) Y. Mastai, M. Homynofer, R. Tenne, G. Hodes “Synthesis of inorganic fullerene-like nanoparticles of metal chalcogenides” Israel patent No.130, 915 1999, PCT-International patent No. WO01/04382, 2002.

    2) Hagit Kun and Y. Mastai "Activity of Short Segments of Type I Antifreeze Protein." USA provisional patent 2009.


    Research Group

    Lab assistance


    Dr. Yochai Basel

    Organic synthesis and characterization

    The main research field of the work is organic synthesis of starting materials to prepare chiral materials for research of the group members and NMR analysis of products and intermediates.


    Zion Elani - (2012-present)

    Main research interests include nanomaterial synthesis, crystallization of nanoparticles, and nanoscale chirality.

    Google Scholar

    Personal website



    1. Elani Z., Space, the Final Frontier: In the Scientific Pursuit of Extraterrestrial Life Away from Earth (PDF, Apr 2020).
    2. Elani Z., Qubit, Quantum Entanglement and all that: Quantum Computing Made Simple (PDF, Jan 2020).
    3. Elani Z., A Spacetime oddity: time dilation and length contraction for the amateur enthusiast (PDF, Nov 2019).
    4. Elani Z., Standing on the Shoulders of Giants: Derivations of Einstein's E=mc2 from Newtonian Laws of Motion (PDF, Jul 2019).
    5. Elani Z., A Brief Pedestrian Derivation of E=mc2 for the Amateur Enthusiasts (PDF, Dec 2018).
    6. Lidor-Shalev O.; Elani Z., Controlled Crystallization of Gold Nanocrystals (IntechOpen, 2015).



    Eitan Elfassi (PhD 2016)

    Chiral ionic liquids

    The influence of long alkyl chains and chiral centers on the structure and properties of ionic liquids at interfaces are studied. Langmuir films of ionic liquids on liquid mercury are studied by tensiometry, surface specific X-ray methods and spectroscopy.  Further applications of chiral ionic liquids for chiral recognition and chiral separation are considered.



    Ortal Lidor-Shalev (PhD 2017)

    Atomic layer deposition of metal-oxides thin films onto chiral biological macromolecule

    This project is designed to produce a new platform for stereoselective applications based on chiral metal-oxide thin films surfaces. The new chiral surfaces are based on biological macromolecules with a complicated spatial structure, used as a model system. The biological molecules are coated with nano-sized metal oxide layers by atomic layer deposition (ALD) process, for obtaining chiral metal oxide surfaces.



    Liora Verber (PhD 2017)

    Chiral polymer nanoparticles synthesis and application for chiral separation

    In our work we prepare chiral polymeric nanoparticles based on the polymerization of N-acryl amino acids monomers in miniemulsion systems (o/w). The chiral nature of those nanoparticles is proven by isothermal titration calorimetry (ITC) of chiral molecules.



    Gila Levi (PhD 2017)

    Chiral silica colloidosomes, synthesis and applications

    Colloidosomes have shown a high potential in a number of technological applications related to encapsulation techniques. The application of the colloidosomes strongly relies on facile and lowcost preparation methods allowing tunable characteristics such as wall thickness, rigidity and porosity. Our aim is to prepare chiral silica colloidosomes in Pickering emulsions and to explore their enantioselective ability in different chiral systems.



    Irena Nemtsov (M.Sc 2015)

    Antifreeze activity of surfaces based on self-assembly of antifreeze proteins

    Antifreeze proteins (AFPs) are unique examples of natural antifreeze materials that have specific interactions with water and ice. AFPs, first found in the blood and tissues of Antarctic and some northern marine fishes, are essential to prevent the fish from freezing at low temperatures. 



    Yehuda Rodal (PhD 2017)

    My research deals with the removal of organic poluutants in water by polymerization methods and using UF membrans.



    Group trips



    Former students:

    Tal Berman (M.Sc 2005), Keren Solomon (M.Sc 2007), David Dressler (PhD 2008), Tali Menahem (PhD 2008), Hagit Kun (PhD 2008), Idan Hod (M.Sc 2008), Yael Katsir (M.Sc 2008), Eti Baruch (PhD 2009), Esthy Levy (PhD 2009), Dana Medina (PhD 2009), Ayelet Shvalbe (PhD 2009), Ruth Frid (PhD 2011), Revital Charbash (M.Sc 2011), Gil Ring (M.Sc 2012), Michal Ejgenberg (PhD 2012), Lihi Rotbart  (Mc.S 2013),  Hagay Moshe (PhD 2014), Ido Fuchs (PhD 2015), Shira Adler (PhD 2015). 









    Visiting Ph.D students and post-doctoral fellows



    Project title


    Dr. Martin Pravda

    Faculty of Pharmacy Charles University Prague, Czech Republic.

    Amino acids block copolymers for enantioselective crystallization.

    10/2004 02/2005


    Grzegorz Wloch

    University of science and technology Krakow, Poland.

    Solution deposition of calcium phosphate powders and thin films.




    Dr. Bezalel Sivan

    Rabin medical center Petah Tikva, Israel.

    Kinetics of dissolution of uric-acid at different pH value.

    10/2007  02/2008

    Dr. Yuliya Alexandrovna

    Al-Farabi national University, Almaty Kazakhstan.

    Developing new sorption materials based on raw materials and their applications.

    03/2009  05/2009

    Dr. Pradip Paik

    Post-Doctorate at my group BIU

    Chrial Silica

    10/2008  10/2010


    Nikolaos Pliatsikas

    PhD student at Aristotle university, Greece

    Characterization of Au nanoparticles 


    Jon Bennion 

    PhD student at the university of michigan, USA

    Cocrystallization of materials



    In the period from 2015 to the present, I have been consulting Ph.D. doctoral students of Al-Farabi Kazakh National University ( of the Faculty of Chemistry and Chemical Technology, the Department of Physical Chemistry, Catalysis, and Petrochemistry. From 2015 till 2019 I led the doctoral candidate Ainur Imangalieva with Professor Gulziya Seilkhanova. In June 2019, she successfully defended the dissertation thesis on the topic of “Sorption and catalytic characteristics of composite materials based on natural raw materials” in the specialty 6D072000 - “Chemical Technology of Inorganic Substances”. The following joint articles were published on the topic of the dissertation:

    1. Seilkhanova G.A., Imangaliyeva Ainur N., Mastai Yitzhak, Rakhym Akmaral B. Bentonite Polymer Composite for Water Purification // Bulletin of Materials Science. - 2019 .-- Vol. 42:60, Issue 2. - P. 1-8. IF: 1,264.

    2. Imangaliyeva Ainur N., Mastai Y., Seilkhanova G.A. In situ synthesis and catalytic properties of Cu2O nanoparticles based on clay materials and polyethylene glycol // Journal of Nanoparticle Research. - 2019. - Vol. 21:97, Issue 5. - P. 1-11. IF: 2.127.

    Currently, research is being carried out with a Ph.D. doctoral student Akmaral Rakhym on the topic of “Physicochemical and Applied Characteristics of New Composite Materials Based on Natural and Technogenic Raw Materials”. In the period from 1.07.2019 to 1.10.2019, Akmaral Rakhym completed an internship under my supervision at the Chirality Nanoscale laboratory of the Department of Chemistry and the Institute of Nanotechnology, Bar-Ilan University.


    During the internship, she mastered SEM/EDAX, XRD, BET, FTIR, UV-VIS spectroscopy methods, carried out the synthesis of composite materials based on zeolite and clay, investigated the sorption characteristics of the composites towards such toxic organic pollutants, as Bisphenol-A and Propranolol Hydrochloride. Based on the results of the internship, an article was prepared for publication. It should be noted that Ph.D. doctoral students have good theoretical knowledge in the field of chemistry and chemical technology, have shown practical skills in organizing an experiment, generalizing and analyzing literature, and interpreting scientific results.



    Prof. Yitzhak Mastai

    Department of Chemistry and

    The Institute of Nanotechnology

    Bar-Ilan University, Israel







    Last Updated Date : 15/03/2023