Seminar: Development of Peptide-Based Tools to Investigate Cell Signaling in Bacteria

24/12/2018 - 13:00 - 12:00Add To Calendar 2018-12-24 12:00:00 2018-12-24 13:00:00 Seminar: Development of Peptide-Based Tools to Investigate Cell Signaling in Bacteria S E M I N A R Monday  24/12/18, 12:00 pm Building 211, seminar room   SPEAKER: Prof. Yftah Tal-Gan Department of Chemistry, University of Nevada, Reno, USA.   TOPIC: Development of Peptide-Based Tools to Investigate Cell Signaling in Bacteria   Quorum sensing (QS) is a ubiquitous process in bacteria that governs many important symbiotic and pathogenic phenotypes. As such, QS has attracted considerable attention as a means to control bacterial behaviors - attenuate undesired phenotypes, and promote productive processes. Many Gram-positive bacterial species utilize peptide pheromones to induce QS responses and initiate pathogenic phenotypes, such as competence, biofilm formation and virulence factor production. We investigate the molecular mechanisms that drive signal: receptor binding while interrogating the role of QS in the competition between bacterial species. To this end, we develop peptide-based QS modulators with distinct activity profiles (selective vs. pan-species modulators; inhibitors vs. activators) to test temporal control of QS modulation in both single-species and mixed cultures. Abstract Department of Chemistry chemistry.office@biu.ac.il Asia/Jerusalem public

S E M I N A R

Monday  24/12/18, 12:00 pm

Building 211, seminar room

 

SPEAKER:

Prof. Yftah Tal-Gan

Department of Chemistry, University of Nevada, Reno, USA.

 

TOPIC:

Development of Peptide-Based Tools to Investigate Cell Signaling in Bacteria

 

Quorum sensing (QS) is a ubiquitous process in bacteria that governs many important symbiotic and pathogenic phenotypes. As such, QS has attracted considerable attention as a means to control bacterial behaviors - attenuate undesired phenotypes, and promote productive processes. Many Gram-positive bacterial species utilize peptide pheromones to induce QS responses and initiate pathogenic phenotypes, such as competence, biofilm formation and virulence factor production. We investigate the molecular mechanisms that drive signal: receptor binding while interrogating the role of QS in the competition between bacterial species. To this end, we develop peptide-based QS modulators with distinct activity profiles (selective vs. pan-species modulators; inhibitors vs. activators) to test temporal control of QS modulation in both single-species and mixed cultures.

Abstract

Last Updated Date : 19/12/2018