Prof. Gil Goobes

Prof.
Associate Professor
Prof. Gil Goobes
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CV

Dr. Gil Goobes completed his undergraduate studies in chemistry in Tel Aviv University in 1993. He received both his M.Sc. and Ph.D. from the department of Chemical Physics at the Weizmann Institute of Science working with Professor Shimon Vega. Through his graduate work he developed pulse techniques in solid state NMR for various applications.

Dr. Gil Goobes held a post-doctoral fellowship at the University of Washington during the period 2002-2007 working with Professor Gary Drobny and Professor Patrick Stayton on deriving the molecular structure of proteins bound to tooth enamel surface, dynamics of DNA molecules and binding of peptides to gold nanoparticles.

Since 2008 he is a member of the chemistry department faculty and is involved in both teaching and research in physical chemistry of heterogeneous biological systems and advanced materials.

Publications

  1. Green, U.; Keinan-Adamsky, K.; Attia, S.; Aizenshtat, Z.; Goobes, G.; Ruthstein, S.; Cohen, H. Elucidating the role of stable carbon radicals in the low temperature oxidation of coals by coupled EPR-NMR spectroscopy – a method to characterize surfaces of porous carbon materials Phys. Chem. Chem. Phys. 2014, 16, 9364-9370.
  2. Zeytuni, N.; Uebe, R.; Maes, M.; Davidov, D.; Baram, M.; Raschdorf, O.; Nadav-Tsubery, M.; Kolusheva, S.; Bitton, R.; Goobes, G.; Friedler, A.; Miller, Y.; Schüler, D.; Zarivach, R.; Initiation and regulation mechanism of cation diffusion facilitators Plos One 2014, 9, e92141
  3. Matlahov, I.; Geiger, Y.; Goobes, G. Trapping RNase A on MCM41 Pores: Effects on Structure Stability, Product Inhibition and Overall Enzymatic Activity Phys. Chem. Chem. Phys. 2013, 16, 9031-9038.
  4. Davidi, I.; Hermida-Merino, D.; Keinan-Adamsky K.; Portale G.; Goobes, G.; Shenhar, R. Dynamic Behavior of Supramolecular Comb Polymers Consisting of Poly(2-Vinyl Pyridine) and Palladium-Pincer Surfactants in the Solid State Chem. Eur. J. 2014, 20, 6951-6959.
  5. Goobes, G.; Past and Future Solid State NMR Studies at the Convergence Point between Biology and Materials Research Isr. J. Chem. 2013, 54, 113-124.
  6. Markovsky, B.; Susai, F.; Talianker, M.; Burlaka, L.; Leifer, N.; Goobes, G.; Erickson, E.; Haik, O.; Grinblat, J.; Zinigrad, E.; Aurbach, D.; Lampert, J.; Shin, J.-Y.; Schulz-Dobrick, M.; Garsuch, A.; Studies of Li and Mn-Rich Lix[MnNiCo]O2 Electrodes: Electrochemical Performance, Structure, and the Effect of the Aluminum Fluoride Coating J. Electrochem. Soc. 2013, 160, A2220-A2233.
  7. Attia, S.; Shames, A.; Zilbermann, I.; Goobes, G.; Maimon, E.; Meyerstein, D.; Covalent binding of a nickel macrocyclic complex to a silica support: towards an electron exchange column Dalton Trans. 2013, 43, 103-110.
  8. Eshed, M.; Keinan-Adamsky, K.; Goobes, G.; Gedanken, A.; Preparation of Ge@Organosilicon Core–Shell Structures and Characterization by Solid State NMR and Other Techniques J. Phys. Chem. C 2013 117, 11086–11094.
  9. Davidi, I.; Semionov, A.; Eisenberg, D.; Goobes, G.; Shenhar, R. Mesomorphic behavior induced by stacking interactions between poly(2-vinyl pyridine) and palladium pincer surfactants in the solid state Soft Matter 2012, 8, 7393-7401.
  10. Ghindes-Azaria, L.; Levy, E.; Keinan-Adamsky, K.; Goobes, G., Conformation and Dynamics of Organic Tethers Bound to MCM41-Type Surfaces from Solid State NMR Measurements J. Phys. Chem. C 2012, 116, 7442-7449.
  11. Haik O.; Leifer, N.; Samuk-Fromovich, Z.; Zinigrad, E.; Markovsky, B.; Larush, L.; Goffer, Y.; Goobes, G.; Aurbach, D. On the Surface Chemistry of LiMO2 Cathode Materials (M=[MnNi] and [MnNiCo]): Electrochemical, Spectroscopic, and Calorimetric Studies. J. Electrochem. Soc. 2010, 157, A1099-A1107.
  12. Amalraj, F.; Kovacheva, D.; Talianker, M.; Zeiri, L.; Grinblat, J.; Leifer, N.; Markovsky, B.; Goobes, G.; Aurbach, D. Synthesis of Integrated Cathode Materials xLi2MnO3·(1-x) LiMn1/3Ni1/3Co1/3O2 (x=0.3, 0.5, 0.7) and Studies of Their Electrochemical Behavior. J. Electrochem. Soc. 2010, 157, A1121-A1130.
  13. Ndao M.; Breen, N.F.; Ash, J.T.; Goobes, G.; Stayton, P.S.; Drobny G. A C-13{P-31} REDOR NMR Investigation of the Role of Glutamic Acid Residues in Statherin- Hydroxyapatite Recognition. Langmuir 2009, 25, 12136–12143.
  14. Echodu, D.; Goobes, G.; Shajani, Z.; Pederson, K.; Meints, G.; Varani, G.; Drobny G. Furanose Dynamics in the HhaI Methyltransferase Target DNA Studied by Solution and Solid-State NMR Relaxation. J. Phys. Chem. B 2008, 112, 13934–13944.
  15. Goobes, G.; Goobes, R.; Shaw, W.J.; Gibson, J.M.; Long, J.R.; Raghunathan, V.; Schueler-Furman, O.; Popham, J.M.; Baker, D.; Campbell, C.T.; Stayton, P.S. Drobny, G.P. The Structure, Dynamics, and Energetics of Protein Adsorption – Lessons Learned from Adsorption of Statherin to Hydroxyapatite. Magn. Reson. Chem. 2007, 45, S32–S47.
  16. Roehrich, A.; Ash, J.; Zane, A.; Masica D.L.; Gray, J.J.; Goobes, G.; Drobny, G. Solid-State NMR Studies of Biomineralization Peptides and Proteins ACS Symposium Series on Proteins at Interfaces III: State of the Art 2012, 1120, 77-96.
  17. Goobes, R.; Goobes, G.; Shaw, W.J.; Campbell, C.T.; Drobny, G.P.; Stayton, P.S. Thermodynamic Roles of Basic Amino Acids in Statherin Recognition of Hydroxyapatite. Biochemistry 2007, 46, 4725-4733.
  18. Goobes, G.; Stayton, P.S.; Drobny, G.P. Solid State NMR Studies of Molecular Recognition at Protein-Mineral Interfaces. Prog. Nucl. Magn. Reson. 2007, 50, 71-85.
  19. Miller, P.A.; Shajani, Z.; Meints, G.A.; Caplow, D.; Goobes, G.; Varani, G.; Drobny, G.P. Contrasting Views of the Internal Dynamics of the HhaI Methyltransferase Target DNA Reported by Solution and Solid-State NMR.  J. Am. Chem. Soc. 2006, 128, 15970-15971.
  20. Goobes, G.; Goobes, R.; Schueler-Furman, O.; Baker, D.; Stayton, P.S.; Drobny, G.P. Folding of the C-terminal Bacterial Binding Domain in Statherin upon Adsorption onto Hydroxyapatite Crystals. Proc. Natl. Acad. Sci. USA 2006, 103, 16083-16088.
  21. Raghunathan, V.; Gibson, J.M.; Goobes, G.; Popham, J.M.; Louie, E.A.; Stayton, P.S.; Drobny, G.P. Study of a Phosphorylated Statherin Fragment Bound to Hydroxyapatite Crystals II, J. Phys. Chem. B 2006, 110, 9324-9332.
  22. Goobes, R.; Goobes, G.; Campbell, C.T.; Stayton, P.S. Thermodynamics of Statherin Adsorption onto Hydroxyapatite by Isothermal Titration Calorimetry.  Biochemistry 2006, 45, 5576-5586.
  23. Goobes, G.; Raghunathan, V.; Louie, E.A.; Gibson, J.M.; Olsen, G.L.; Drobny, G.P. A REDOR Study of Diammonium Hydrogen Phosphate: A Model for Distance Measurements from Adsorbed Molecules to Surfaces. Solid State Nuc. Magn. Reson. 2006, 29, 210-218.
  24. Goldbourt, A.; Vinogradov, E.; Goobes, G.; Vega, S. High resolution heteronuclear correlation NMR spectroscopy between quadrupolar nuclei and protons in the solid state, J. Magn. Reson. 2004, 169, 342-350.
  25. Goobes, G.; “Structural Determination Using Spectral Selective MAS NMR Techniques”, Ph.D. Thesis, Feinberg Graduate School, Weizmann Institute of Science, May 2003, Supervisor: Professor Shimon Vega. (publications 11-15 are included in thesis)
  26. Goobes, G.; Vinogradov, E.; Vega, S. Selective Polarization Inversion in High Resolution Solid State NMR of Protons, J. Magn. Reson. 2003, 161, 56-63.
  27. Goobes, G.; Vega, S. Improved Narrowband Dipolar Recoupling for Homonuclear Distance Measurements in Rotating Solids, J. Magn. Reson. 2002, 154, pp. 1-16.
  28. Goobes, G.; Boender, G.-J.; Vega, S. Spinning-Frequency-Dependent Narrowband RF-Driven Dipolar Recoupling, J. Magn. Reson. 2000, 146, 204-219.

Courses

Physical Chemistry 2
Theory and applications of solid state NMR
Selected topics in physical chemistry - graduate level
Seminar course in physical chemistry - graduate level
Seminar course in physical chemistry - undergraduate level
Physical chemistry laboratory
Instrumental chemistry laboratory

 

Research

The scientific work in my research group focuses on utilization of solid state NMR spectroscopy and other physical chemistry and biophysical techniques for both materials and biological surface studies.

Select research projects we are currently exploring include:

Structural biology of proteins involved in hard tissue construction and maintenance in humans and other organisms.

Development of tools for molecular structure and binding characterization of proteins bound to the surfaces of solid substrates.

Study of advanced nanomaterials for use in contemporary batteries.

Preparation of biomaterials inspired by natural enzymes for efficient degradation of cellulose and production of alternative chemical fuels.

Research Group

Dr Merav Tsubery
Irena Matlahov
Taly Vul
Yasmin Geiger

Alex Kulpanovich
Rotem Gavriel