Prof. Abraham Nudelman

Prof.
Prof. Abraham Nudelman
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Guiding the research students: 

CV

Address                     Miller 15, Rehovot, ISRAEL

Date of Birth              December 22, 1939

Nationality                 Mexican, Israeli

email                          Nudelman@biu.ac.il

Phone/Fax                972-3-531-8314

 

Education

June 1961                 B. Sc. in Chemistry from Bar-Ilan University. Ramat Gan, Israel.

 

February 1964          M. Sc. in Chemistry from Brooklyn College. New York, under the supervision of Prof. Paul Haberfield.

 

February 1969          Ph. D. from The University of California at Los Angeles. UCLA, under the supervision of Nobel Prize Laureate Prof. Donald J. Cram.

 

Employment

1969-1975                 Research chemist at the Medicinal Chemistry Division of Wyeth Laboratories Inc., Radnor, Pennsylvania.

 

1975-1981                 Emigrated to Israel in March 1975 and joined the Organic Chemistry Department of the Weizmann Institute of Science, Rehovot.

 

1981-to date              Chemistry Department of Bar-Ilan University, Ramat Gan, Israel. Coordinator of the Medicinal Chemistry Division.

 

1981-to date              Invited lecturer of Medicinal Chemistry at The Weizmann Institute of Science. Israel.

 

April 1986                  Associate Professor of Chemistry, Bar Ilan University, Ramat Gan, Israel.

 

Summer 1986           Visiting Professor at the Chemistry Department, Johns Hopkins University, Baltimore, MD.

 

Summer 1987           Visiting Professor at the Chemistry Department, California State University, Los Angeles, CA.

 

1989-1990                 Sabbatical year at E. I. Du Pont de Nemours Central Research Division, Wilmington, DE.

 

Summers 1991/93   Visiting scientist at E. I. Du Pont de Nemours Central Research Division, Wilmington, DE.

 

1993-1996                 Chairman, Chemistry Department Bar Ilan University, Ramat Gan, Israel.

 

April 1994                  Professor of Chemistry, Bar Ilan University, Ramat Gan, Israel.

 

October 1998-2009  Head of the “Marcus Center for Medicinal Chemistry” at Bar Ilan University

 

October 2008            Professor Emeritus

Publications

NMR chemical shifts of common laboratory solvents as trace impurities. H. E. Gottlieb, V. Kotlyar and A. Nudelman. J. Org. Chem. 1997, 62, 7512-7515. **This article is the “Most Read” and one of the  “Most Cited” papers in the history of the Journal of Organic Chemistry. It has been cited in 2500 publications  

NMR chemical shifts of trace impurities: Common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist. G. R. Fulmer, A. J. M. Miller, N. H. Sherden, H. E. Gottlieb, A. Nudelman, B. M. Stoltz, J. E. Bercaw, K. I. Goldberg. Organometallics 2010, 29, 2176-2179. This article has been cited close to 1100 time

The Story of ALA Photodynamic Therapy: A Cancer Enigma. Z. Malik, A. Nudelman. In “Photodynamic Medicine: From Bench to Clinic”. The Royal Society of Chemistry, 2016

Development of GSK’s NMR Guides – A tool to encourage the use of more sustainable solvents. H. E. Gottlieb, G. Graczyk-Millbrandt, G. G. A. Inglis, A. Nudelman, D. Perez, Y. Qian, L. E. Shuster, H. F. Sneddon, R. J. Upton. Green Chem. 2015, 18, 3867-3878

Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin-independent manner. A. Rephaeli, N. Tarasenko. E. Fibach, G. Rozic, I Lubin, J. Lipovetsky, S. Furman. Z. Malik, A. Nudelman. Europ. J. Pharm. Sci. 2016, 91, 91-97.

Indoline-3-propionate and 3-aminopropyl carbamates reduce lung injury and pro-inflammatory cytokines induced in mice by LPSE. Finkin-Groner, D. Moradov, H. Shifrin, C. Bejar, A. Nudelman, M. Weinstock. Brit. J. Pharmacol. 2014, 172, 1101-1113

Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages. S. Furman, E. Bardugo Nissim, S. Zeeli, M. Weitman, A. Nudelman, E. Finkin-Groner, D. Moradov, H. Shifrin, D. Schorer-Apelbaum, M. Weinstock. Bioorg. Med. Chem. Lett. 2014, 24, 2283-2287

ALA induced heme synthesis: Fine tuning mechanisms of PBG deaminase and ALA dehydratase. Z. Malik, G. Breovich-Luria, A. Nudelman, A. Rephaeli. J. Hematol. Thrombol. Dis. 2014, 2, 135. http:dx.doi.org/10.4172-8790.1000135

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo. N. Tarasenko, S. M. Cutts, D. R. Phillips, G. Berkovitch-Luria, E. Bardugo-Nissim, M. Weitman, A. Nudelman, A. Rephaeli. Biochem. Pharmacol. 2014, 88, 158-168

Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways. G. Berkovitch-Luria, M. Weitman, A. Nudelman, A. Rephaeli, Z. Malik. Invest. New Drugs 2012, 30, 1028-38.

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity. Tarasenko, N., Kessler-Icekson, G., Boer, P., A., Schlesinger, H., Phillips, D. R., Cutts, S. M., Nudelman, A., Rephaeli, A. Invest. New Drugs 2012, 30, 130-143.

A Multifunctional 5-aminolevulinic acid derivative induces erythroid differentiation of K562 human erythroleukemic cells. G. Berkovitch-Luria, S. Yakobovitch, M. Weitman, A. Nudelman, G. Rozic, A. Rephaeli, Z. Malik.  Europ. J. Phar. Sci., 2012, 47, 206-214

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation. R. A. Forrest, L. P. Swift, A. Rephaeli, A. Nudelman, K. Kimura, D. R. Phillips, S. M. Cutts. Biochem. Phamacol. 2012, 83, 1602-1612

Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer’s disease. I. Yanovski, E. Finkin-Groner, A. Zaikin, L. Lerman, H. Shalom, S. Zeeli, T. Billig, I. Ginsburg, A. Nudelman, M. Weinstock. J. Med. Chem. 2012, 55, 10700-10715

Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing mammary tumor. N. Tarasenko, S. M. Cutts, D. R. Phillips, A. Inbal, A. Nudelman, G. Kessler-Icekson, A. Rephaeli. PLoS ONE 2012, 7, e31393.

Research

Medicinal Chemistry Division

Chemistry Department

Bar Ilan University

 

Summary of active projects

 

Anti-schizophrenic agents

In collaboration of scientists from Tel Aviv University a new compound, labeled BL-1020, has been licensed to the pharmaceutical company BiolineRX, Jerusalem, for the treatment of schizophrenia, a disease which affects about 1% of the population. The compound has successfully completely Phase I and Phase II clinical trails for the treatment of schizophrenia and was found to be a potent and effective anti-schizophrenic drug which elicits significantly diminished side effects in comparison with drugs currently in clinical use. Moreover, in the course of the Phase II study it was found that BL-1020 induces highly desirable cognitive improving qualities to the patients. Based on the data generated, a second human Phase II clinical study has been initiated with the goal of specifically evaluating the cognitive improving properties of the drug. The final results are expected in early 2013 and lead to the expectation that similar cognitive enhancement may be achieved in other central nervous diseased patients including those suffering from Alzheimer’s disease. It should be noted that no drug is in the marked, which deals with cognition improvement.

 

Drugs against neuropathic pain

 A second drug developed in collaboration with scientists from Tel Aviv University that has also been licensed to BiolineRX, Jerusalem, and labeled BL-1021, has been found to be highly promising for the treatment of neuropathic pain. The various types of neuropathic pain affect between 2-3% of the world population. In model studies the compound was found to be safe and very efficacious.  BL-1021 has successfully completed safety Phase I clinical studies I and is scheduled to begin Phase II studies for efficacy.

 

Neroprotectant and anti-inflammatory agents.

In collaboration with Prof. Marta Rosin from the Hebrew University Prof. Nudelman has developed a family of compounds that show potential activity against both Parkinson and Alzheimer diseases and are considered to be neuroprotectants. Moreover the investigators have shown that some of the compounds possess potent anti-inflammatory activity, which is expected to be useful in the clinic for a variety of diseases where inflammation is a major factor in the disease.

 

Photodynamic skin treatment

In collaboration with Prof. Zvi Malik of the Life Sciences Faculty of Bar Ilan, Prof. Nudelman has developed novel derivatives of 5-aminolevulinic acid for photodynamic treatment of skin cancer. The results were significan and highly promising. Moreover, these substances appear to be potent catalysts for the enhancement of hemoglobin levels and are expected to be useful in the treatment of anemias and severe bleeding. The compounds have been patented and extensive studies are being conducted for further development.

 

Professor Nudelman who established the Medicinal Chemistry Division of the Chemistry Department at Bar Ilan University, has published more than 150 papers in scientific journals and is the holder of more than 88 patents in various fields of medicinal chemistry and drug development.