פרופ' שי רהימיפור

פרופ'
מרצה בכיר
פרופ' שי רהימיפור
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דוא"ל: 
משרד: 

קורות חיים

 

Education

1990-1993

B.Sc., Chemistry - Bar-Ilan University, Ramat-Gan, Israel

 

1993-2001                

M.Sc./ Ph.D. (combined), Organic Chemistry and Neurobiology, The Weizmann Institute of Science, Rehovot, Israel. Subject: Potential Cytotoxic Derivatives of Gonadotropin-Releasing Hormone (GnRH): Synthesis and Biological Evaluation. Supervisors: Prof. Mati Fridkin and Yitzhak Koch, Department of Organic Chemistry and Neurobiology,

2001 – 2003               

Post-Doctoral Research Fellow, Chemistry and Photobiology, The Weizmann Institute of Science, Rehovot, Israel. Subject: Design, synthesis and biological evaluation of Hypericin and its analogs as potential agents for photodynamic therapy (PDT). Supervisor: Prof. Yehuda, Mazur

 

2003-2006                  

Post-Doctoral Research Fellow, Chemistry, The Scripps Research Institute, La Jolla, California. Subject: Self-assembled cyclic D,L-a-peptide and cyclic D,L-a-glycopeptides nanotubes as antibacterial and anticancer agents. Supervisor: Prof. M. Reza Ghadiri

 

Positions

2006-present              

Senior Lecturer, Department of Chemistry, Bar-Ilan University.

 

Other professional activities

2007-present              

Member in editorial board of ARKIVOC Journal.

2007-2008

Member of the Organizing Committee of the 6th Medicinal Chemistry Conference, The Weizmann Inst. of Science.

 

Awards and fellowships

2003-2006                  

Human Frontier Science Program (HFSP) long-term fellowship for postdoctoral research.

2003-2004                  

Fulbright Postdoctoral fellowship

June 2000                   

CaP CURE award for proposed research on new drug discovery

July 1999                    

ESCOM Awards for most outstanding poster relevant to drug discovery.

פירסומים

 

 

  1. Rahimipour, S.; Weiner, L.; Fridkin, M.; ShresthaDawadi, P. B.; Bittner, S., Novel naphthoquinonyl derivatives: Potential structural components for the synthesis of cytotoxic peptides. Lett. Pept. Sci. 1996, 3, 263-274.
  2. ShresthaDawadi, P. B.; Bittner, S.; Fridkin, M.; Rahimipour, S., On the synthesis of naphthoquinonyl heterocyclic amino acids. Synthesis 1996, 1468-1472.
  3. Rahimipour, S.; Weiner, L.; Shrestha-Dawadi, P. B.; Bittner, S.; Koch, Y.; Fridkin, M., Cytotoxic peptides: Naphthoquinonyl derivatives of luteinizing hormone-releasing hormone. Lett. Pept. Sci. 1998, 5, 421-427.
  4. Yahalom, D.; Chen, A.; Ben-Aroya, N.; Rahimipour, S.; Kaganovsky, E.; Okon, E.; Fridkin, M.; Koch, Y., The gonadotropin-releasing hormone family of neuropeptides in the brain of human, bovine and rat: identification of a third isoform. FEBS Lett. 1999, 463, 289-294.
  5. Sack, I.; Balazs, Y. S.; Rahimipour, S.; Vega, S., Solid-state NMR determination of peptide torsion angles: Applications of H-2-dephased REDOR. J. Am. Chem. Soc. 2000, 122, 12263-12269.
  6. Yahalom, D.; Rahimipour, S.; Koch, Y.; Ben-Aroya, N.; Fridkin, M., Structure-activity studies of reduced-size gonadotropin-releasing hormone agonists derived from the sequence of an endothelin antagonist. J. Med. Chem. 2000, 43, 2824-2830.
  7. Yahalom, D.; Rahimipour, S.; Koch, Y.; Ben-Aroya, N.; Fridkin, M., Design and synthesis of potent hexapeptide and heptapeptide gonadotropin-releasing hormone antagonists by truncation of a decapeptide analogue sequence. J. Med. Chem. 2000, 43, 2831-2836.
  8. Braverman, S.; Zafrani, Y.; Rahimipour, S., Base catalyzed [2,3]-sigmatropic rearrangements of propargylic sulfonium and selenonium salts. Tetrahedron Lett. 2001, 42, 2911-2914.
  9. Chen, A. L.; Yahalom, D.; Laskar-Levy, O.; Rahimipour, S.; Ben-Aroya, N.; Koch, Y., Two isoforms of gonadotropin-releasing hormone are coexpressed in neuronal cell lines. Endocrinology 2001, 142, 830-837.
  10. Rahimipour, S.; Ben-Aroya, N.; Fridkin, M.; Koch, Y., Design, synthesis, and evaluation of a long-acting, potent analogue of gonadotropin-releasing hormone. J. Med. Chem. 2001, 44, 3645-3652.
  11. Rahimipour, S.; Bilkis, I.; Peron, V.; Gescheidt, G.; Barbosa, F.; Mazur, Y.; Koch, Y.; Weiner, L.; Fridkin, M., Generation of free radicals by emodic acid and its [D-Lys(6)]GnRH-conjugate. Photochem. Photobiol. 2001, 74, 226-236.
  12. Rahimipour, S.; Palivan, C.; Freeman, D.; Barbosa, F.; Fridkin, M.; Weiner, L.; Mazur, Y.; Gescheidt, G., Hypericin derivatives: Substituent effects on radical-anion formation. Photochem. Photobiol. 2001, 74, 149-156.
  13. Sack, I.; Balazs, Y. S.; Rahimipour, S.; Vega, S., Peptide torsion angle measurements: Effects of nondilute spin pairs on carbon-observed, deuterium-dephased PM5-REDOR. J. Magn. Reson. 2001, 148, 104-114.
  14. Chen, A.; Ganor, Y.; Rahimipour, S.; Ben-Aroya, N.; Koch, Y.; Levite, M., The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. Nature Med. 2002, 8, 1421-1426.
  15. Chen, A.; Kaganovsky, E.; Rahimipour, S.; Ben-Aroya, N.; Okon, E.; Koch, Y., Two forms of gonadotropin-releasing hormone (GnRH) are expressed in human breast tissue and overexpressed in breast cancer: A putative mechanism for the antiproliferative effect of GnRH by down-regulation of acidic ribosomal phosphoproteins P1 and P2. Cancer Res. 2002, 62, 1036-1044.
  16. Rahimipour, S.; Ben-Aroya, N.; Ziv, K.; Chen, A.; Fridkin, M.; Koch, Y., Receptor-mediated targeting of a photosensitizer by its conjugation to gonadotropin-releasing hormone analogues. J. Med. Chem. 2003, 46, 3965-3974.
  17. Rahimipour, S.; Palivan, C.; Barbosa, F.; Bilkis, I.; Koch, Y.; Weiner, L.; Fridkin, M.; Mazur, Y.; Gescheidt, G., Chemical and photochemical electron transfer of new helianthrone derivatives: Aspects of their photodynamic activity. J. Am. Chem. Soc. 2003, 125, 1376-1384.
  18. Di-Segni, S.; Giordano, C.; Rahimipour, S.; Ben-Aroya, N.; Koch, Y.; Fridkin, M., beta-Sulfonamido gonadotropin-releasing hormone analogs: synthesis and evaluation of several parent hormone properties. J. Pept. Sci. 2005, 11, 45-52.
  19. Nicolaou, K. C.; Zak, M.; Rahimipour, S.; Estrada, A. A.; Lee, S. H.; O'Brate, A.; Giannakakou, P.; Ghadiri, M. R., Discovery of a biologically active thiostrepton fragment. J. Am. Chem. Soc. 2005, 127, 15042-15044.
  20. Rahimipour, S.; Litichever-Coslovsky, N.; Alaluf, M.; Freeman, D.; Ehrenberg, B.; Weiner, L.; Mazur, Y.; Fridkin, M.; Koch, Y., Novel methyl helianthrones as photosensitizers: Synthesis and biological evaluation. Photochem. Photobiol. 2005, 81, 250-258.
  21. Fridkin, G.; Rahimipour, S.; Ben-Aroya, N.; Kapitkovsky, A.; Di-Segni, S.; Rosenberg, M.; Kustanovich, I.; Koch, Y.; Gilon, C.; Fridkin, M., Novel cyclic azo-bridged analogs of gonadotropin-releasing hormone. J. Pept. Sci. 2006, 12, 106-115.
  22. Motiei, L.; Rahimipour, S.; Thayer, D. A.; Wong, C. H.; Ghadiri, M. R., Antibacterial cyclic D,L-alpha-glycopeptides. Chem. Comm. 2009, 3693-3695.
  23. Rahimipour, S.; Gescheidt, G.; Bilkis, I.; Fridkin, M.; Weiner, L., Towards the Efficiency of Pharmacologically Active Quinoid Compounds: Electron Transfer and Formation of Reactive Oxygen Species. Appl. Magn. Reson. 2010, 37, 629-648.
  24. Skirtenko, N.; Tzanov, T.; Gedanken, A.; Rahimipour, S., One-Step Preparation of Multifunctional Chitosan Microspheres by a Simple Sonochemical Method. Chem. Eur. J. 2010, 16, 562-567.
  25. Skirtenko, N. Richman, M., Nitzan, Y. Gedanken, A. Rahimipour, S. A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria. Chem. Commun. 2011, 47, 12277-12279 (Cover).
  26. Richman, M., Wilk, S., Skirtenko, N., Perelman, A., Rahimipour, S. Surface-Modified Protein Microspheres Capture Amyloid-β and Inhibit its Aggregation and Toxicity. Chem. Eur. J. 2011, 17, 11171-11177 (Cover)
  27. Shalev, T., Gopin, A., Bauer, M., Stark, R.W., Rahimipour, S. Non-leaching antimicrobial surfaces through polydopamine bio-inspired coating of quaternary ammonium salts or an ultrashort antimicrobial lipopeptide. J. Mater. Chem. In Press. DOI:10.1039/C1JM13994K.
  28. Baram-Pinto, D., Shukla, S., Richman, M., Gedanken, A., Rahimipour, S.*, Sarid, R*. Surface-modified protein microspheres as potential antiviral agents. In Press.
  29. Richman, M., Perelman, A., Rahimipour, S. Effective targeting of Ab to macrophages by sonochemically prepared surface-modified protein microspheres. Submitted for Publication.

 

קורסים

 

Organic chemistry (Life Science students)

Organic chemistry laboratory

Seminars in Bio-Organic Chemistry

Seminars in Organic Chemistry

Biochemistry (I and II)

תחומי מחקר

Neurodegenerative diseases (Multiple Sclerosis, Alzheimer’s Disease, Parkinson's Disease), supramolecular chemistry, Peptide Chemistry, Combinatorial Chemistry, Drug design

פטנטים

 

  1. Koch, Y., Fridkin, M., Rahimipour, S. GnRH conjugates comprising a photosensitizer for photodynamic therapy.  PCT Int. Appl. 2004, 59 pp, WO 2004098629, A1 20041118, CAN 141:427990, AN 2004:995998
  2. Koch, Y., Fridkin, M., Rahimipour, S.  Synthesis of long-acting gonadotropin-releasing hormone analogs and therapeutic use thereof.  PCT Int. Appl. 2004, 63 pp, WO 2004030687, A1 20040415, CAN 140:31565, AN 2004:310981
  3. Richman, M. and Rahimipour, S. The Capture and Macrophage-Aided Clearance of Amyloid Beta by Surface-Modified Proteinaceous Microspheres through a Non-amyloid Beta-Mediated Mechanism. Provisional Patent Application 2010
  4. Shapiro, R. and Rahimipour, S. Cyclic peptides as neuroprotecting agents. Provisional Patent Application 2011