פרופ' בלהה פישר

פרופ'
פרופסור מן המנין
פרופ' בלהה פישר
טלפון: 
פקס: 
משרד: 
שעות קבלה: 

קורות חיים

בלהה פישר

 

  • פרופ' מן המניין במחלקה לכימיה, אונ' בר-אילן.
  • ניסיון מקצועי: ראש קבוצת מחקר בתחום של כימיה תרופתית ודיאגנוסטיקה. לקבוצה שיתופי פעולה רבים עם אקדמיה ותעשיה בארץ ובחו"ל.
  • תואר שני בכימיה תרופתית בהנחיית פרופ' א. נודלמן (כימיה של סוכרים), אונ' בר-אילן.
  • תואר שלישי בכימיה אורגנית בהנחיית פרופ' א. הסנר (כימיה הטרוציקלית), אונ' בר-אילן.
  • פוסט-דוקטורט בהנחיית דר' ק. ג'ייקובסון (כימיה של נוקלאוסידים ונוקליאוטידים, מודלים מולקולרים), מכוני הבריאות האמריקאים, בתסדה, מרילנד, ארה"ב.
  • כימיה תרופתית, ביוכימיה, כימיה אי-אורגנית, כימיה ביו-אי-אורגנית, סמינר ביו-אורגני, מעבדה בכימיה אורגנית.
  • כ-100 מאמרים ו-10 פטנטים.
  • תפקידים אקדמיים בעבר: הועד המנהל של החברה הישראלית לכימיה, ועדת מלגות, הועדה לתואר שני, הועדה לתואר שלישי, שופטת בוועדה של הקרן הישראלית למדעים, שופטת בקרן פולברייט למלגות לפוסט דוקטורנטים, חברה בועדת הוראה מחלקתית, חברה בועדת המינויים העליונה של אונ' בר-אילן, ראש המחלקה, יועצת הרקטור לקידום נשים באקדמיה, כיום חברת סנאט.
  • פרס טבע למדענים צעירים מצטיינים, פרס יולדן (טכניון) ליישום מדעים מדויקים לרפואה, פרס שוהם לאמנויות.

 

אני מאמין

 

כללי: אני מאמינה שישראל בשל היותה מחוסרת אוצרות טבע, צריכה להתמקד במשאבי האנוש שלה ובמיוחד במדענים ובמהנדסים, ע"מ לקדם את כלכלתה. אנו כמדענים צריכים לקחת חלק במאמץ לקדם את המדע בישראל.

 

פיתוח תרופות: אני מאמינה שככימאים תרופתיים אנו לוקחים חלק ב"תיקון עולם", כלומר, אנו עושים את העולם טוב יותר. זוהי חובתנו וזוהי זכותנו.

 

תעשייה: כיום קיים פער מסוים בין האקדמיה והתעשייה שעליו, אני מאמינה, יש לגשר ע"י מיזמים משותפים שונים.

 

קהילה: אני מאמינה שהאקדמיה דומה למערת האוצרות של אלאדין. את אינסוף אוצרות הידע שבה צריך לחלוק עם הקהילה.

פירסומים

1.     A Novel Method for Stereoselective Glucuronidation. Fischer, B.; Nudelman, A.; Ruse, M.; Hertzig, J.; Gottlieb H. E.; Keinan, E. J. Org. Chem. 1984, 49, 4993-4988.

2.     Studies in Sugar Chemistry. 2. A Simple Method for O-Deacetylation of Polyacylated Sugars. Hertzig, J.; Nudelman, A.; Gottlieb H. E.; Fischer, B. J. Org. Chem. 1986, 51, 727-730.

3.     4,5 and 2,5-Additions to Oxazoles. Hassner, A.; Fischer, B. Tetrahedron, 1989, 45, 6249-6262.

4.     Do Oxazoles Undergo Diels-Alder Reactions with Heterodienophiles? Hassner, A.; Fischer, B. Tetrahedron, 1989, 45, 3535-3546.

5.     Nitrile Additions to C, N-Diacylimines. Formation of 4-Amidooxazoles. Hassner, A.; Fischer, B. J. Org. Chem. 1990, 55, 5225-5229.

6.     Intramolecular Formation of Oxazolium Salts and their Reaction with N- and C-Nucleophiles. Hassner, A.; Fischer, B. Tet. Lett. 1990, 31, 7213-7214.

7.     Novel Heterocycles by Bis Heteroannulation of Oxazoles. Hassner, A.; Fischer, B. J. Org. Chem. 1991, 56, 3419-3425.

8.     Multipath Reactions between Intramolecularly Formed Oxazolium Salts and Nucleophiles. Hassner, A.; Fischer, B. J. Org. Chem. 1992, 57, 3070-3075.

9.     Unusual Transformations of Azomethine Yilides Including an Unsymmetrical Dimerization. Fischer, B.; Hassner, A.; Wolk, J. L. Acta Chem. Scand. 1993, 47, 191-195.

10.   New Chemistry of Oxazoles. Hassner, A.; Fischer, B. Heterocycles 1993, 35, 1441-1465.

11.   Structure Activity Relationships of 8-Styrylxanthines as A2 Selective Adenosine Antagonists. Gallo-Rodriguez, C.; Melman, N.; Fischer, B.; Maillard, M.; van Bergen, A.; van Galen, P. J. M.; Katon, Y.; Jacobson, K. A. J. Med. Chem. 1993, 36, 1333-1342.

12.   Structure Activity Relationships for 2-Thioether Derivatives of Adenosine-5’-triphosphate as Agonists at P2 Purinoceptors. Fischer, B.; Boyer, J. L.; Hoyle, C.; Ziganshin, A.; Ralevic, V.; Knight G.; Brizzolara, A.; Zimmet, J.; Burnstock, G.; Harden, T. K.; Jacobson, K. A. J. Med. Chem. 1993, 36, 3937-3946.

13.   Structure Activity Relationships for Derivatives of Adenosine-5’-triphosphate Agonists at P2 Purinoceptors. Burnstock, G.; Fischer, B.; Maillard, M.; Boyer, J. L.; Hoyle, C.; Ziganshin, A.; Ralevic, V.; Knight G.; Brizzolara, A.; von Isakovics, A.; Harden, T. K.; Jacobson, K. A. Drug Dev. Res. 1994, 31, 206-219.

14.   Comparative Studies on the Affinities of ATP Derivatives to P2X-Purinoceptors in Rat at Urinary Bladder. Bo, X.; Fischer, B.; Maillard, M.; Jacobson, K. A.; Burnstock, G. Br. J. Pharm. 1994, 112, 1151-1159.

15.   Structure Activity Relationships of N6-Bezyladenosine-5’-uronamides as A3 Adenosine Agonists. Gallo-Rodriguez, C.; X.-D. Ji; Melman, N.; Siegman, B. D.; Sanders, L. H.; Orlina, J.; Fischer, B.; Pu, Q.; Olah, M. E.; van Galen, P. J. M.; Stiles, G. L.; Jacobson, K. A. J. Med. Chem. 1994, 37, 636-646.

16.   2-Thioether derivatives of adenine nucleotides are exceptionally potent agonists at adenylyl cyclase-linked P2Y-purinoceptors. Boyer, J. L.; O’Tuel J. W.; Fischer, B.; Jacobson, K. A.; Harden, T. K. Br. J. Pharmacol. 1995, 116, 2611-2616.

17.   Modeling the P2Y purinoceptor using rhodopsin as template. van Rhee, A. M.; Fischer, B.; van Galen, P. J. M.; Jacobson, K. A. Drug Desig. Deliv. 1995, 13, 133-154.

18.   A ‘cleavable Trifunctional’ approach to receptor affinity labeling: regeneration of binding to A1-adenosine receptors. Jacobson, K. A.; Fischer, B.; X.-D. Ji. Bioconj. Chem. 1995, 6, 255-263.

19.   Molecular probes for muscarinic Receptors: Functionalized congeners of selective muscarinic antagonists. Jacobson, K. A.; Fischer, B.; van Rhee, A. M. Life Sci. 1995, 56, 823-830.

20.   Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5’-monophosphate. Boyer, J. L.; Siddiqi, S.; Fischer, B.; Romero-Avila, T.; Jacobson, K. A.; Harden, T. K. Br. J. Pharmacol. 1996, 116, 1959-1964.

21.   Diethyl chlorophosphite – A mild reagent for efficient reduction of nitro compounds to amines. Fischer, B.; Sheihet, L. J. Org. Chem. 1998, 63, 393-395.

22.   Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-tert-Boc-protective group. Bechor, Y.; Falb, E.; Fischer, B.; Wexler, B.A.; Nudelman, A. Syn. Comm. 1998, 28, 471-474.

23.   Therapeutic aApplications of ATP-(P2)-receptors agonists and antagonists. Fischer, B.; Sheihet, L. Exp. Opin. Therp. Patents 1999, 9, 385-399.

24.   Characterization of mini-nucleotides as P2X-receptor agonists in rat cardiocyte culture. An Integrated Synthetic, Biochemical and Theoretical Study. Fischer, B.; Yefidoff, R.; Major, D. T.; Rutman-Halili, I.; Shneyvays, V.; Zinman, T.; Jacobson, K. A.; Shainberg, A. J. Med. Chem. 1999, 42, 2685-2696.

25.   2-Thioether-5’-O-(1-thiotriphosphate) adenosine derivatives as new insulin secretagogues acting through P2Y-receptors. Fischer, B.; Chulkin, A.; Boyer, J. L.; Harden, T. K.; Gendron, F.-P.; Beaudoin, A. R.; Chapal, J.; Hillaire-Buys, D.; Petit, P. J. Med. Chem. 1999, 42, 3636-3646.

26.   Molecular recognition of modified adenine nucleotides by the P2Y1-receptor. I. A synthetic, biochemical and NMR approach. Halbfinger, E.; Major, D. T.; Ritzmann, M.; Ubl, J.; Reiser, G.; Boyer, J. L.; Harden, T. K.; Fischer, B.; J. Med. Chem. 1999, 42, 5325-5337.

27.   Molecular recognition of modified adenine nucleotides by the P2Y1-receptor. II. A computational approach. Major, D. T.; Halbfinger, E.; Fischer, B. J. Med. Chem. 1999, 42, 5338-5347.

28.   A facile synthesis of (15N2) malononitrile. Laxer, A.; Fischer, B. J. Label. Comp. Radiopharm. 2000, 43, 47-53.

29.   Synthesis, mechanism and properties of 8-(aryl)-3-b-D-ribofuranosylimidazo [2,1-i] purine 5’-phosphate derivatives. Fischer, B.; Kabha, E.; Gendron, F.-P.; Beaudoin, A. R. Nucleosides and Nucleotides 2000, 19, 1033-1054.

30.   Novel nucleoside triphosphate diphosphohydrolase inhibitors: Synthesis, biochemical and pharmacological characterization. Gendron, F.-P.; Halbfinger, E.; Fischer, B.; Duval, M.; D’Orleans-Juste, P.; Beaudoin, A. R. J. Med. Chem. 2000, 43, 2239-2247.

31.   P2-Receptor agonists – From molecular recognition studies to potential clinical applications. Fischer, B. Drug Dev. Res. 2000, 50, 338-354.

32.   Inhibitors of NTPDase: Key players in the metabolism of extracellular purines. Gendron, F.P.; Halbfinger, E;. Fischer, B.; Beaudoin, A.R Advan. Experiment. Biol. 2000, 486, 119-123.

33.   Novel adenosine 5’-triphosphate analogue with potential for P2Y1-receptor isolation pharmacologically characterized in HEK 293 cells highly expressing the rat brain P2Y1-reecptor. Zundorf, G.; Schafer, R.; Vohringer, C.; Halbfinger, E.; Fischer, B.; Reiser, G. Biochem. Pharmacol. 2001, 61, 1259-1269.

34.   (15N5)-Labeled adenine derivatives. Synthesis and tautomerism studies by 15N NMR spectroscopy and theoretical calculations. Laxer, A.; Major, D. T.; Gottlieb, H.; Fischer, B. J. Org. Chem. 2001, 66, 5463-5481.

35.   2-Thioether-5’-O-(1-thiotriphosphate) adenosine derivatives as new insulin secretagogues acting through P2Y-receptors. II. Pharmacological evaluation and chemical stability of 2-benzylthioether-5’-O-(1-thiotriphosphate)-adenosine. Hillaire-Buys, D.; Shahar, L. M.; Fischer, B.; Chulkin, A.; Linck, N.; Chapal, J.; Loubatieres-Mariani, M. M.; Petit, P. Drug Dev. Res. 2001, 53, 33-43.

36.   Diethyl chlorophosphite – a versatile reagent. Jie, Z.; Rammoorty, V.; Fischer, B. J. Org. Chem. 2002, 67, 711-719.

37.   Protonation studies of modified adenine and adenine nucleotides by theoretical calculations and 15N NMR. Major, D. T.; Laxer, A.; Fischer, B. J. Org. Chem. 2002, 67, 790-802.

38.   5’-O-(1-Boranotriphosphate)-adenosine derivatives as novel P2Y1-receptor agonists. Nahum, V.; Ubl, J.; Reiser, G.; Levesque S.; Beaudoin, A. R.; Fischer B. J. Med. Chem. 2002, 45, 5384-5396.

39.   Characterization and elucidation of coordination requirements of adenine nucleotides complexes with Fe(II). Richter, Y.; Fischer, B. Nucleosides Nucleotides Nucleic Acids 2003, 22, 1757-1780.

40.   Photoaffinity labeling on magnetic microspheres (PALMm) methodology for topographic mapping: preparation of PALMm reagents and demonstration of biochemical relevance. Halbfinger, E.; Gorochesky, K.; Levesque, S. A.; Beaudoin, A. R.; Sheihet, L.; Margel, S.; Fischer, B. Org. Biomol. Chem. 2003, 1, 2821 - 2832.

41.   Theoretical study of the pH-dependent photophysics of N1,N6-ethenoadenine and N3,N4-ethenocytosine. Major, D. T. and Fischer, B. J. Phys. Chem. 2003, 107, 8923 - 8931.

42.   Inorganic boranophosphate: A novel inorganic phosphate mimic. Preparation, Characterization, and Properties. Nahum, V. and Fischer, B. Eur. J. Inorg. Chem. 2004, 4124 - 4131.

43.   Molecular recognition in purinergic receptors. Part 1. A comprehensive computational study of the h-P2Y1-receptor. Major, D. T. and Fischer, B. J. Med. Chem. 47, 2004, 4391-4404.

44.   Molecular recognition in purinergic receptors. Part 2. Stereo- and diastereo-selectivity of the h-P2Y1-receptor. Major, D. T., Nahum, V., Y. Wang, G. Reiser, and B. Fischer. J. Med. Chem. 47, 2004, 4405-4416.

45.   Subtype specific internalization of P2Y1 and P2Y2 receptors induced by novel adenosine 5’-O-(1-boranotriphosphate) derivatives. Tulapurkar, M. E.; Laubinger, W.; Nahum, V.; Fischer B.; Reiser, G. Br. J. Pharmacol. 2004, 142, 869-878.

46.   Fluorescent ATP analogues for probing physicochemical properties of proteins. Synthesis, biochemical evaluation, and sensitivity to physicochemical properties of the medium. E. Sharon, G. Zündorf, S. A. Levesque, A. R. Beaudoin, G. Reiser, and B. Fischer. Bioorg. Med. Chem. 2004, 12, 6119-6135.

47.   Diadenosine- and diuridine-poly(borano)phosphate analogues: Synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2-receptors. V. Nahum, M. Tulapurkar, S. A. Levesque, J. Sevigny, G. Reiser, and B. Fischer. J. Med. Chem. 2006, 49, 1980-1990.

48.   Fluorescent N2,N3-e-Adenosine: Synthesis and Spectroscopic Properties. E. Sharon, A. Levesque, D. Ecke, J. Sevigny, G. Reiser, and B. Fischer. ChemBioChem, 2006, 7, 1361-1374.

49.   Nucleotides and inorganic phosphates as potential antioxidants. Y. Richter, and B. Fischer. J. Biol. Inorg. Chem. 2006, 11, 1063-1074.

50.   Opposite diastereoselective activation of P2Y1 and P2Y11 nucleotide receptors by adenosine 5'-O-(1-boranotriphosphate) analogues. D. Ecke, M. Tulapurkar, V. Nahum, B. Fischer, and G. Reiser. Br. J. Pharmacol. 2006, 149, 416 – 423.

51.   Molecular recognition of adenosine deaminase. 15N NMR studies. A. Laxer, H. E. Gottlieb, and B. Fischer. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26, 161-180.

52.   Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis. J. Zylberg, D. Ecke, B. Fischer, and G. Reiser. Biochem. J. 2007, 405, 277-286.

53.   Can nucleotides prevent Cu-induced oxidative damage? R. Baruch-Suchodolsky and B. Fischer. J. Inorg. Biochem. 2008, 102, 862-881.

54.   Cu(I)/Cu(II)/Fe(II)-Complexes of soluble Aβ1-28 are potent antioxidants. R. Baruch-Suchodolsky and B. Fischer. Biochemistry, 2008, 47, 7796-7806.

55.   Diastereoselectivity of the P2Y11 nucleotide receptor: mutational analysis. D. Ecke, B. Fischer, G. Reiser. Br. J. Pharmacol. 2008, 155, 1250-1255.

56.   Identification of hydrolytically stable and selective P2Y1-receptor agonists. S. Elyahu, J. Camden, J. Lecka, G. A. Weisman, J. Sévigny, S. Gélinas, and B. Fischer. Eur. J. Med. Chem. 2009, 44, 1525-1536.

57.   Aβ40, either soluble or aggregated, is a remarkably potent antioxidant in cell – free oxidative systems. R. Baruch-Suchodolsky and B. Fischer. Biochemistry, 2009, 48, 4354-4370.

58.   5-OMe-UDP is a potent and selective P2Y6-receptor agonist. T. Ginsburg-Shmuel, M. Haas, M. Schumann, G. Reiser, O. Kalid, N. Stern, and B. Fischer. J. Med. Chem., 2010, 53, 1673–1685.

59.   Oligonucleotides as potent antioxidants. E. Zobel, E. Yavin, H. E. Gottlieb, M. Tzion, and B. Fischer, JBIC, 2010, 15, 601-620.

60.   A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold. S. Eliahu, H. M. Barr, J. Camden,  G. A. Weisman, and B. Fischer. J. Med. Chem., 2010, 53, 2472–2481.

61.   2-MeS-β,γ-CCl2-ATP is a potent agent for reducing intraocular pressure. S. Eliahu, A. Martín-Gil, M. Perez de Lara, J. Camden, G. A. Weisman, J. Lecka, J. Sévigny and B. Fischer. J. Med. Chem., 2010, 53, 3305–3319.

62.   An improved one-pot synthesis of nucleoside 5’-triphosphate analogues. I. Gillerman and B. Fischer. Nucleosides, Nucleotides and Nucleic Acids 2010, 29, 245-256.

63.   Neither Ab28 nor a combination of Ab28 and physiological reductants trigger enhanced production of OH radical in cell - free oxidizing systems. R. Baruch-Suchodolsky and B. Fischer. 2010, submitted to publication.

64.   What is the conformation of physiologically-active dinucleoside polyphosphates in an aqueous solution? Conformational analysis of free dinucleoside polyphosphates by NMR and molecular dynamics simulations. N. Stern, D. T. Major, H. E. Gottlieb, D. Weizman, B. Fischer. Org. Biomol. Chem. 2010, 8, 4637 - 4652.

65.   Diadenosine Poly(borano)phosphate analogues as specific NPP inhibitors. S. Eliahu, J. Lecka, G. Reiser, F. Bigonnesse, J. Sévigny, and B. Fischer. J. Med. Chem., 2010, 53, 8485-8497.

66.   Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors. I. Gillerman and B. Fischer J. Med. Chem., 2011, 54, 107-121.

67.   8-(p-CF3-cinnamyl)-modified purine nucleosides as promising fluorescent probes.  L. Zilbershtein, A. Silberman, and B. Fischer. Org. Biomol. Chem. 2011, 9 (22), 7763 – 7773.

68.   Identification of Dinucleoside Poly(borano)phosphate Analogues as Selective and Stable P2Y Receptor Agonists. S. Yelovitch, J. Camden, G. A. Weisman, and B. Fischer. J. Med. Chem., 2012, 55, 437-448.

69.   Minimally Extended Fluorescent Uridine Analogues as Potential Probes for Detection of Genetic Material. Synthesis and Spectral Properties of Uridine Analogues. Meirav Segal and B. Fischer. Org. Biomol. Chem. 2012, 10 (8), 1571 – 1580.

70.   Studies of Mg2+/Ca2+ complexes of naturally occurring dinucleotides: potentiometric titrations, NMR, and molecular dynamics N. Stern, D. T. Major, H. E. Gottlieb, D. Weizman, A. H. Sayer, E. Blum and B. Fischer. J. Biol. Inorg. Chem. 2012, 17, 861-879..

71.   Nucleoside-5’-phosphorothioate Analogues are Biocompatible Antioxidants Dissolving Efficiently Amyloid Beta –Metal Ion Aggregates. A. Amir, E. Shmuel, R. Zagalsky, A. Sayer, Y. Kogon, and B. Fischer. Dalton Transactions, 2012, 41, 8539 – 8549.

72.   UDP Made a Highly Promising Stable, Potent, and Selective P2Y6-Receptor Agonist upon Introduction of a Boranophosphate Moiety. T. Ginsburg-Shmuel, M. Haas, M. Schumann, G. Reiser, Y. Nadel, and B. Fischer. Bioorg. Med. Chem., 2012, 20, 5483-5495.

73.   Identification of a Promising Insulin Secretagogue Based on a P2Y1 Receptor Agonist. Yelovitch, S.; Barr, H.; Camden, J.; Weisman, G.; Shai, E.; Varon, D.; Fischer, B. J Med Chem, 2012, 55, 7623−7635.

74.   A Novel Scaffold: O,O’-Diester-methylenediphosphonotetrathioate- Synthesis, Characterization, and Potential Applications. A. Amir, R. Zagalsky, L. J. W. Shimon and B. Fischer. 2012, J Org Chem, 2013, 78, 270-277.

75.   8-BuS-ATP derivatives as specific NTPDase1 inhibitors. by Lecka, J.; Gillerman, I.; Munkonda, M.; Brosseau, J.-P.; Cadot, C.; Fausther, M.; Martín-Satué, M.; D'Orléans-Juste, P.; Rousseau, E.; Poirier, D.; Künzli, B.; Fischer, B.; Sévigny, J. Br. J. Pharmacol, 2013. 169(1):179-96.

76.   Methylenediphosphonotetrathioate: Synthesis, Characterization, and Chemical Properties A. Amir, A. H. Sayer, A. Ezra, and B. Fischer. Inorg Chem., 2013, 52, 3133-40.

77.   p-Substituted-Phenyl-Imidazolo-Cytidine Analogues as Potential Fluorescent Probes. M. Kovaliov, M. Segal, and B. Fischer. Tetrahedron, 69, 2013, 3698-3705.

78.   Phosphorothioate Nucleotide Derivatives as Oxidative Stress Protectants in PC12 Cells. O. Danino, S. Grossman, and B. Fischer. Nucleosides, Nucleotides and Nucleic Acids, 32, 1–21, 2013.

79.   Selective detection of mRNA of Cyclin D1 breast cancer marker by a novel duplex-DNA probe. M. Segal, E. Yavin, and B. Fischer. . J Med Chem 56, 4860-4869, 2013.

80.   Highly Efficient Biocompatible Neuroprotectants with Dual-activity as Antioxidants and P2Y-Receptor Agonists. S. Azran, D. Forster, O. Danino, Y. Nadel, G. Reiser and B. Fischer. J Med Chem, 56, 4938-4952, 2013.

81. Sp-2-propylthio-ATP-α-B and Sp-2-propylthio-ATP-α-B,β-γ-dichloromethylene are novel potent and specific agonists of the human P2Y11 receptor. Haas M., Ben-Moshe I., Fischer B., Reiser G. Biochem Pharmacol, 86, 645-655, 2013.

82. Adenosine-5'-α-borano, β,γ-dihalomethylene- tri-phosphate analogues as potent and selective NPP inhibitors. J. Lecka, G. Ben-David, S. Eliahu, J. Pelletier, J. Oscar Jr., P. Luyindula, B. Fischer, H. Senderowitz, and J. Sévigny. J Med Chem, 56, 8308-8320, 2013.

83. Characterization of Complexes of Nucleoside-5’-Phosphorothioate Analogues with Zinc Ions. A. H. Sayer, Y. Itzhakov, N. Stern, Y. Nadel and B. Fischer. Inorg. Chem., 52, 10886–10896, 2013.

84. Rules for the design of highly fluorescent probes: 8-(substituted cinnamyl)-adenosine analogues. Lital Zilbershtein, Michal Weitman, Dan-Thomas Major, and Bilha Fischer. J. Org. Chem. 78(23):11999-2008, 2013.

85. Nucleoside-2’,3’/3’,5’-Bis(thio)phosphate Analogues are Promising Antioxidants Acting Mainly via Cu+/Fe2+ Ion Chelation. B. Levi Hevroni, A. H. Sayer, E. Blum, and B. Fischer. Inorg. Chem. 53, 1594–1605, 2014.

86. Nucleoside 5'-phosphorothioate derivatives are highly effective neuroprotectants. O. Danino, N. Giladi, S. Grossman, and B. Fischer. Biochem. Pharmacol. 88, 384-392, 2014.

87. 5-OMe-uridine-5’-O-(α-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y6 receptor protects against death-receptor mediated glial apoptosis. M. Haas, T. Ginsburg-Shmuel, B. Fischer, G. Reiser, accepted to publication, Neuroscience Letters, 578, 80-4, 2014.

88. Detection of Cyclin D1 mRNA by hybridization sensitive NIC - oligonucleotide probe. M. Kovaliov, M. Segal, P. Kafri, E. Yavin, Y. Shav-Tal, and B. Fischer. Bioorg. Med. Chem. 22, 2613-2621, 2014.

89. Development of fluorescent double-strand probes labeled with 8-(p-CF3-cinnamyl)-adenosine for the detection of cyclin D1 breast cancer marker L. Zilbershtein-Shklanovsky,  P. Kafri, Y. Shav-Tal, E. Yavin, and B. Fischer. E. J. Med. Chem., 79, 77-88, 2014.

90. Highly potent and selective NPP1 inhibitors based on ATP - (α or γ) thio - (α, β or β, γ)-methylene scaffold. Y. Nadel, Y. Gliad, J. Lecka, G. Ben-David, H. Sendrowitz, J. Sévigny, D. Förster, G. Reiser, J. Camden, G. A. Weisman, and B. Fischer. J. Med. Chem. 57, 4677–4691, 2014.

91. 2-Hexylthio-β, γ -CH2-ATP is a specific NTPDase2 inhibitor. I. Gillerman, J. Lecka, L. Simhaev, M. N. Munkonda, M. Fausther, M. Martín-Satué, H. Senderowitz, J. Sévigny, and B. Fischer. J. Med. Chem. 57 (14), 5919–5934, 2014.

92. Phenyl-Imidazolo-Cytidine Analogues: Structure-Photophysical-Activity Relationship and Potential Use for SNP Typing. M. Kovaliov, M. Weitman, D. T. Major, and B. Fischer. J. Org. Chem. 79(15):7051-62, 2014.

93. Novel Cu(I)-Selective Chelators Based on a Bis(phosphorothioyl)amide Scaffold.

Fischer, B.; Amir, A.; Ezra, A. Inorg. Chem. 53(15):7901-8, 2014.

94. Synthesis and Evaluation of a Novel Photoresponsive Quencher for Fluorescent Hybridization Probes. M. Kovaliov, C. Wachtel, E. Yavin, and B. Fischer. Org. Biomol. Chem. 12, 7844-7859, 2014.

95. Adenosine/Guanosine-3',5’-Bis-Phosphate as Biocompatible and Selective Zn2+-Ion Chelators. Characterization and Comparison with Adenosine/Guanosine-5’-Di-Phosphate. A. H. Sayer, E. Blum, D. T. Major, A. Vardi-Kilshtain, B. Levi Hevroni, and B. Fischer. Dalton Trans. 44, 7305-7317, 2015.

96. ATP-γ-S-(α,β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Ortal Danino, Shlomo Grossman and Bilha Fischer. BBRC, 460, 446-450, 2015.

97. Synthesis and Characterization of Novel Crown-Ether-Methylenediphosphonotetrathioate Chimeras Capable of Simultaneously Binding Zn2+ and Na+ Ions. Diana Meltzer, Aviran Amir, Linda J. W. Shimon, and Bilha Fischer. Chemistry Eur J. Submitted. April 2015

98. Synthesis and Structure-Activity Relationship of Uracil Nucleotide Derivatives as Antagonists of Human P2Y6 Receptor. Diana Meltzer, Ofir Ben Yaacov, Guillaume Arguin, Yael Nadel, Fernand-Pierre Gendron, and Bilha Fischer. ChemMedChem. Submitted. April 2015

99. Identification of Highly Promising Anti-Oxidants / Neuroprotectants Based on Nucleoside Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. Sagit Azran, Ortal Danino, Daniel Forster, Sarah Kenigsberg, Georg Reiser and Bilha Fischer. J. Med. Chem. Submitted.April 2015.

100. Nucleoside-2’,3’/3’,5’-Bis(thio)phosphate Analogues Dissolve Efficiently Amyloid Beta(1-42)–Metal Ion Aggregates. Bosmat Levi Hevroni, and Bilha Fischer. Dalton Trans. Submitted.April 2015.

תחומי מחקר

 

פטנטים

Patents

 

1.       Biologically Active ATP Analogues. Fischer, B.; Maillard, M.; Jacobson, K. A. US5620676, 1997.

2.       8-Substituted 1,3,7-Trialkyl-Xanthine Derivatives. Jacobson, K. A.; Karton, Y.; Gallo-Rodriguez, C.; Fischer, B.; van Galen, P. J. M.: Maillard, M.; US5861405, 1997.

3.       C8 Substituted Purine Nucleotide Analogues. Gendron, F.-P.; Halbfinger, E.; Beaudoin, A. R.; Fischer, B. US patent 6,617,439, 2003.

4.       Antidiabetic 2-Substituted-5’-O-(1-Boranophosphate) Adenosine Derivatives. Fischer, B.; Kleiman, V.; Linck, N.; Chapal, J.; Petit, P. US Patent (pending) 10/493,461, SA patent (pending) 2004/2697, 2004.

5.       Inorganic Boranophosphate Salts. Fischer, B.; Nahum, V. US Patent No. 7,338,669, 2008.

6.       Fluorescent N2,N3-etheno purine (2'-deoxy) riboside derivatives and uses thereof. Fischer, B.; Sharon E. Patent No. 7,385,051, 2008.

7.       Antidiabetic diuridine poly(borano)phosphate derivatives. Fischer, B.; Nahum, V. US Patent No. 7,319,093, 2008.

8.       Dinucleoside poly(borano)phosphate derivatives and uses thereof. Fischer, B.; Nahum, V. Patent No. 7,368,439, 2008.

9.       Non-Hydrolyzable Nucleoside di- or tri- Derivatives and Uses Thereof. Fischer, B.;                          Elyahu, S.; Yellovich S. PCT Application No. IL2008/001535, 2008.

 

10.     Inorganic phosphate derivatives, nucleotides and oligonucleotide antioxidants. Provisional patent. Fischer, B.; Richter, Y; Baruch, R.; Zion Meirav. Application No. 61/213,397, 2009.

11.     A potent agent for reducing intraocular pressure. Fischer, B.; Elyahu, S.; Pintor, J. US Prov. Application No. 61/282,133, 2009.

12.     Nucleoside 5'-phosphorothioate analogues and uses thereof. CIP appl. no.: 14/479,181, B. Fischer, O. Shimon, Y. Nadel, U. Arad; 2014.

קבוצת מחקר

 

 

קבוצת המחקר (2014)

 

כדי להכיר את קבוצתנו מקרוב

הביטו בלינק טוב טוב

 

Bilha Fischer's Lab -- אני והתרופה שלי

(זהו הסרטון הזוכה בתחרות הסרטונים במחלקה לכימיה 2012)

קבוצת המחקר (נובמבר 2013)